Devuyst, Olivier
[UCL]
Lefebvre, Chantal
[UCL]
Geubel, André
[UCL]
Coche, Edgard
[UCL]
We report a case of acute cholestatic hepatitis associated with rash and hypereosinophilia, in which the absence of transfusion, intercurrent viral infection, alcohol consumption or other hepatotoxic drugs are suggestive of ranitidine-induced hepatotoxicity. The pathogenesis of the disorder is unknown, but the lack of a dose-effect relationship, the rarity and unpredictability of the reaction, as well as the clinical signs suggest that hypersensitivity is involved. Physicians should be aware of this rare and idiosyncratic side-effect of ranitidine.
Bibliographic reference |
Devuyst, Olivier ; Lefebvre, Chantal ; Geubel, André ; Coche, Edgard. Acute cholestatic hepatitis with rash and hypereosinophilia associated with ranitidine treatment.. In: Acta clinica Belgica, Vol. 48, no. 2, p. 109-14 (1993) |
Permanent URL |
http://hdl.handle.net/2078.1/27882 |