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Anti-HCV seroconversion in multitransfused and immunocompromised patients : A long-term longitudinal study

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Cornu, Chantal [UCL] Brusselmans, Caroline [UCL] Geubel, André [UCL] Ferrant, Augustin [UCL] Cornu, Guy [UCL]

In a series of 6 multitransfused, immunocompromised patients, the diagnosis of posttransfusion hepatitis C was based upon the analysis of long-term follow-up serum samples. The HCV RNA was detected by a nested PCR assay using primers located in the 5' noncoding region (5'NCR), and anti-HCV antibodies were assayed with third-generation tests. The interval between the first rise in alanine aminotransferase and seroconversion varied from less than 5 months to more than 38 months. Five out of 6 patients seroconverted after 14 months or later. In most cases, the anti-NS3 and anti-NS4 antibodies appeared first. In such patients, the etiology of chronic liver disease may thus be overlooked for 1 or more years, a definitive diagnosis requiring the detection of HCV RNA.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "Vox Sanguinis : international journal of transfusion medicine" - Vol. 67, no. 3, p. 286-290 (1994)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 0042-9007
e-issn 1423-0410
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hépato-gastro-entérologie
UCL - (SLuc) Service d'hématologie
MESH Subject Adult ; Alanine Transaminase - blood ; Blood Transfusion - adverse effects ; Bone Marrow Transplantation ; Child ; Follow-Up Studies ; Hematologic Diseases - complications - therapy ; Hepacivirus - isolation & purification ; Hepatitis Antibodies - blood ; Hepatitis C - enzymology - epidemiology - immunology - transmission - virology ; Hepatitis C Antibodies ; Humans ; Immunocompromised Host ; Incidence ; Polymerase Chain Reaction ; RNA, Viral - blood ; Viremia - virology
Links
  1. Kuo, Science, 244, 362 (1989)
  2. Choo, Br Med Bull, 46, 423 (1990)
  3. Houghton, Hepatology, 14, 381 (1991)
  4. Aach, N Engl J of Med, 325, 1325 (1991)
  5. Frosner, Infection, 19, 434 (1991)
  6. McHutchinson, Hepatology, 15, 19 (1992)
  7. Wang, Vox Sang, 62, 21 (1992)
  8. Fong T.-L., Valinluck B., Govindarajan S., Rolon N., Lee S. R., Page E., Darner J., Redeker A. G., Marked Improvement in Sensitivity of Second-Generation Tests for Acute Hepatitis C Virus Infection, 10.1093/infdis/168.2.519
  9. García-Samaniego J., Enríquez A., Soriano V., Gutierrez M., Baquero M., Muñoz F., Third-Generation Recombinant Immunoblot Assay to Confirm Hepatitis C Virus-Indeterminate Serological Samples, 10.1111/j.1423-0410.1993.tb05384.x
  10. Chomczynsky, Anal Biochem, 162, 156 (1987)
  11. Imberti, J Virol Meth, 34, 233 (1991)
  12. Alter, J Gastroenterol Hepatol, 78 (1990)
  13. Lelie, J Med Virol, 37, 203 (1992)
  14. Aoki, Blood, 82, 1000 (1993)
  15. Lok, Hepatology, 18, 497 (1993)
  16. Brink, Br J Haematol, 83, 498 (1993)
Bibliographic reference Cornu, Chantal ; Brusselmans, Caroline ; Geubel, André ; Ferrant, Augustin ; Cornu, Guy. Anti-HCV seroconversion in multitransfused and immunocompromised patients : A long-term longitudinal study. In: Vox Sanguinis : international journal of transfusion medicine, Vol. 67, no. 3, p. 286-290 (1994)
Permanent URL http://hdl.handle.net/2078.1/27197