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Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue

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Devogelaer, Jean-Pierre [UCL] Azria, M. Attinger, M. Abbiati, G. Castiglioni, C. Nagant de Deuxchaisnes, C. [UCL]

In most countries, calcitonin is available in the form of injections, and less frequently as an intranasal spray. An oral route of administration should improve compliance. In a preliminary feasibility study, we have compared the acute biological action of injectable salmon calcitonin (50 IU), with the injectable calcitonin analogue ASC 710 (0.2 mg) and oral ASC 710 (20 mg) in 6 patients suffering from active Paget's disease of bone. The intensity and duration of the biological response were not significantly different in the 3 modes of therapy. In conclusion, the oral calcitonin analogue ASC 710 possesses an antiresorbing activity in Paget's disease comparable to that of an injection of salmon calcitonin which demonstrates that it can cross the intestinal barrier.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "Calcified Tissue International" - Vol. 55, no. 1, p. 71-73 (1994)
Peer reviewed yes
Publisher Springer New York LLC (New York)
issn 0171-967X
e-issn 1432-0827
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de rhumatologie
MESH Subject Administration, Intranasal ; Administration, Oral ; Aged ; Bone Resorption - drug therapy ; Calcitonin - administration & dosage - pharmacology - therapeutic use ; Chromatography, High Pressure Liquid ; Feasibility Studies ; Female ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Osteitis Deformans - drug therapy
Keywords Calcitonin ; Oral ; Analogue ; Paget's disease
Links
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Bibliographic reference Devogelaer, Jean-Pierre ; Azria, M. ; Attinger, M. ; Abbiati, G. ; Castiglioni, C. ; et. al. Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue. In: Calcified Tissue International, Vol. 55, no. 1, p. 71-73 (1994)
Permanent URL http://hdl.handle.net/2078.1/26384