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Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.

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Byl, Baudouin Jacobs, Frédérique Wallemacq, Pierre [UCL] Rossi, Camelia de Francquen, Philippe Leal, Teresinha [UCL] Thys, Jean-Pierre

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2003
Journal information "Antimicrobial agents and chemotherapy" - Vol. 47, no. 6, p. 2015-7 (2003)
Peer reviewed yes
issn 0066-4804
Publication status Publié
Affiliation UCL
MESH Subject Adult ; Aged ; Anti-Bacterial Agents - administration & dosage - blood - pharmacokinetics ; Area Under Curve ; Bronchial Neoplasms - drug therapy - metabolism ; Drug Administration Schedule ; Exudates and Transudates - metabolism ; Female ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Pleural Effusion, Malignant - metabolism ; Vancomycin - administration & dosage - blood - pharmacokinetics
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Bibliographic reference Byl, Baudouin ; Jacobs, Frédérique ; Wallemacq, Pierre ; Rossi, Camelia ; de Francquen, Philippe ; et. al. Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.. In: Antimicrobial agents and chemotherapy, Vol. 47, no. 6, p. 2015-7 (2003)
Permanent URL http://hdl.handle.net/2078.1/26222