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Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter.

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Haddam, Nahida Samira, Sekkal Dumont, Xavier Taleb, Abdesselem Haufroid, Vincent [UCL] Lison, Dominique [UCL] Bernard, Alfred [UCL]

Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO(2)) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO(2) and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO(2) interacted synergistically to decrease serum CC16 but not to increase serum SP-D. While further illustrating the potential of serum CC16 and SP-D, our study confirms that SO(2) can cause airways damage at exposure levels below current occupational exposure limits.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2009
Journal information "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals" - Vol. 14, no. 5, p. 292-8 (2009)
Peer reviewed yes
issn 1354-750X
e-issn 1366-5804
Publication status Publié
Affiliations UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Centre de toxicologie clinique
UCL - (SLuc) Service de biochimie médicale
MESH Subject Adult ; Biological Markers - blood ; Dust ; Epithelium - injuries - metabolism ; Humans ; Inhalation Exposure ; Lung Injury - blood - chemically induced - physiopathology ; Male ; Occupational Exposure ; Pulmonary Surfactant-Associated Protein D - blood ; Smoking - adverse effects ; Sulfur Dioxide - toxicity ; Uteroglobin - blood
Links
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Bibliographic reference Haddam, Nahida ; Samira, Sekkal ; Dumont, Xavier ; Taleb, Abdesselem ; Haufroid, Vincent ; et. al. Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter.. In: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 14, no. 5, p. 292-8 (2009)
Permanent URL http://hdl.handle.net/2078.1/25847