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Diagnosis of suspected Alzheimer's disease is improved by automated analysis of regional cerebral blood flow.

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Tang, Bich-Ngoc-Thanh [UCL] Minoshima, Satoshi Georges, Jean [UCL] Robert, Annie [UCL] Swine, Christian [UCL] Laloux, Patrice [UCL] Vander Borght, Thierry [UCL]

PURPOSE: Accurate diagnosis of Alzheimer's disease (AD), the most common form of dementia, remains difficult. In order to assess whether fully automated stereotactic surface projection (3D-SSP) presentation contributes to the diagnosis of AD by single-photon emission computed tomography (SPECT), we investigated the diagnostic accuracy of transaxial display with and without 3D-SSP analysis as well as the correlation between cerebral perfusion in different cortical areas and the mini mental score (MMS). METHODS: Seventy-two patients referred because of cognitive impairment were included in the study. According to the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's disease and Related Disorders Association (ADRDA) criteria, 27 patients were diagnosed as having probable AD while 45 were classified as non-AD patients. 3D-SSP was used to quantify the regional cerebral blood flow (rCBF) acquired from SPECT imaging. RESULTS: Compared with the transaxial section presentation alone, 3D-SSP presentation improved the area under the receiver operating curve (p<0.05) as well as intra-observer (k=0.73 vs 0.88) and inter-observer (k=0.50 vs 0.84) reproducibility. Upon normalisation of regional to thalamic activity, multiple regression analysis revealed a strong correlation between the MMS and rCBF in the right parietal cortex (p=0.002). CONCLUSION: Addition of 3D-SSP to the transaxial section display of ECD-SPECT studies improves the reproducibility and the diagnostic performance in respect of AD in patients with cognitive impairment and provides a valid tool for assessment of the severity of cortical perfusion abnormalities in such patients.

Document type Article de périodique (Journal article) – Article de recherche – Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2004
Language Anglais
Journal information "European journal of nuclear medicine and molecular imaging" - Vol. 31, no. 11, p. 1487-94 (2004)
Peer reviewed yes
issn 1619-7070
Publication status Publié
Affiliations UCL - (MGD) Service de neurologie
UCL - MD/ESP - Ecole de santé publique
UCL - MD/NOPS - Département de neurologie et de psychiatrie
UCL - (MGD) Service de médecine nucléaire
UCL - (MGD) Service de médecine gériatrique
UCL - (SLuc) Service de gériatrie
MESH Subject Adult ; Aged ; Aged, 80 and over ; Algorithms ; Alzheimer Disease - classification - physiopathology - radionuclide imaging ; Artificial Intelligence ; Blood Flow Velocity ; Brain - blood supply - radionuclide imaging ; Brain Mapping - methods ; Cerebrovascular Circulation ; Female ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index
Links
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Bibliographic reference Tang, Bich-Ngoc-Thanh ; Minoshima, Satoshi ; Georges, Jean ; Robert, Annie ; Swine, Christian ; et. al. Diagnosis of suspected Alzheimer's disease is improved by automated analysis of regional cerebral blood flow.. In: European journal of nuclear medicine and molecular imaging, Vol. 31, no. 11, p. 1487-94 (2004)
Permanent URL http://hdl.handle.net/2078.1/25832