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Antimutagenic effects of natural and synthetic hormonal steroids.

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Wilpart, M. Speder, A Ninane, Paul [UCL] Roberfroid, Marcel [UCL]

Among the steroid molecules, bile acids have been shown to have either a co- or an antimutagenic activity toward various direct and indirect acting mutagens in the Ames test. The present report extends such observations to other steroids having hormonal activity. The main effect of the active hormones is an inhibition of the genotoxicity of both direct and indirect acting mutagens. This effect is strictly structure-related. Moreover, both ethinyl oestradiol and mestranol, which are synthetic derivatives of beta-oestradiol largely used in contraceptive pills, are strong inhibitors of the mutagenicity, acting at nanomolar concentrations. The present article emphasizes the possible role of compounds with steroid structure as modulators of genotoxicity.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article
Publication date 1986
Journal information "Teratogenesis, carcinogenesis, and mutagenesis" - Vol. 6, no. 4, p. 265-73 (1986)
issn 0270-3211
Publication status Publié
Affiliation UCL
MESH Subject Bile Acids and Salts - physiology ; Dehydroepiandrosterone - analysis - chemical synthesis - pharmacology - physiology - toxicity ; Estradiol - pharmacology ; Mestranol - pharmacology ; Methylnitronitrosoguanidine - pharmacology ; Mutagenicity Tests ; Mutation ; Salmonella typhimurium - drug effects ; Structure-Activity Relationship
Links
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Bibliographic reference Wilpart, M. ; Speder, A ; Ninane, Paul ; Roberfroid, Marcel. Antimutagenic effects of natural and synthetic hormonal steroids.. In: Teratogenesis, carcinogenesis, and mutagenesis, Vol. 6, no. 4, p. 265-73 (1986)
Permanent URL http://hdl.handle.net/2078.1/25098