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Today's treatments: medical, surgical and in partnership.

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Donnez, Jacques [UCL]

OBJECTIVE: To provide an overview of the medical, surgical and combined therapy options for endometriosis. RESULTS: Available medical options include danazol, progestogens, gestrinone, oral contraceptive agents, analgesics and gonadotropin-releasing hormone (GnRH) agonists. Used in the short-term, most of these agents relieve pain in a large proportion of patients and produce disease regression, however, they do not prevent recurrence, and are associated with side-effects. However, few data confirm any benefit of short-term medical therapy on fertility. One of the most promising medical approaches appears to be GnRH agonists with add-back hormone replacement therapy. Surgery may relieve pain, eradicate visible disease and improve fertility. A combined approach may facilitate surgery and relieve pain, although any fertility benefit is as yet unproven. CONCLUSION: Both short-term medical treatment and surgery relieve endometriosis-associated pain and decrease endometriotic implants. However, all approaches have side effects which must be balanced against the benefits when defining suitable treatment for a particular patient.

Document type Article de périodique (Journal article) – Journal Article, Review
Publication date 1999
Journal information "International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics" - Vol. 64 Suppl 1, p. S5-13 (1999)
Peer reviewed yes
issn 0020-7292
Publication status Publié
Affiliation UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
MESH Subject Endometriosis - drug therapy - surgery - therapy ; Female ; Gynecologic Surgical Procedures ; Humans ; Laparoscopy
Links
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Bibliographic reference Donnez, Jacques. Today's treatments: medical, surgical and in partnership.. In: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, Vol. 64 Suppl 1, p. S5-13 (1999)
Permanent URL http://hdl.handle.net/2078.1/24149