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HLA gene and haplotype frequencies in spina bifida. Population and family studies.

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De Bruyère, Marc [UCL] Kulakowski, S Malchaire, Jacques [UCL] Delire, M. Sokal, G. [UCL]

The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effects of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Gene frequency of HLA-B5 and haplotype frequency of A2, B5 were increased without reaching signification levels. Fourteen families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found without evidence of linkage with HLA haplotypes.

Document type Article de périodique (Journal article) – Journal Article
Publication date 1977
Journal information "Tissue antigens" - Vol. 10, no. 5, p. 399-402 (1977)
Peer reviewed yes
issn 0001-2815
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/ESP - Ecole de santé publique
MESH Subject Adolescent ; Alleles ; Child ; Child, Preschool ; Female ; Gene Frequency ; HLA Antigens - analysis ; Humans ; Infant ; Infant, Newborn ; Male ; Spina Bifida Occulta - genetics
Links
Bibliographic reference De Bruyère, Marc ; Kulakowski, S ; Malchaire, Jacques ; Delire, M. ; Sokal, G.. HLA gene and haplotype frequencies in spina bifida. Population and family studies.. In: Tissue antigens, Vol. 10, no. 5, p. 399-402 (1977)
Permanent URL http://hdl.handle.net/2078.1/22599