Bosca, L.
Mojena, M
Ghysdael, J
Rousseau, Guy
[UCL]
Hue, Louis
[UCL]
The concentration of fructose 2,6-bisphosphate and the activity of 6-phosphofructo-2-kinase are increased after infection of chick-embryo fibroblasts with the Rous sarcoma virus, or with a temperature-sensitive mutant of this virus at the permissive, but not at the non-permissive, temperature. This is observed after transformation by retroviruses carrying either the v-src or v-fps, but not the v-mil and/or v-myc, oncogenes. Comparison of the effects of the Rous sarcoma virus with those of phorbol myristate acetate on fructose 2,6-bisphosphate suggests that both result from the stimulation of a step which is rate-limiting for 6-phosphofructo-2-kinase activation and which is also controlled by protein kinase C.
Bibliographic reference |
Bosca, L. ; Mojena, M ; Ghysdael, J ; Rousseau, Guy ; Hue, Louis. Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.. In: The Biochemical journal, Vol. 236, no. 2, p. 595-9 (1986) |
Permanent URL |
http://hdl.handle.net/2078.1/21648 |