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MTBindingSim: simulate protein binding to microtubules

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Philip, Julia T. Pence, Charles H. [UCL] Goodson, Holly V.

Summary: Many protein–protein interactions are more complex than can be accounted for by 1:1 binding models. However, biochemists have few tools available to help them recognize and predict the behaviors of these more complicated systems, making it difficult to design experiments that distinguish between possible binding models. MTBindingSim provides researchers with an environment in which they can rapidly compare different models of binding for a given scenario. It is written specifically with microtubule polymers in mind, but many of its models apply equally well to any polymer or any protein–protein interaction. MTBindingSim can thus both help in training intuition about binding models and with experimental design.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2012
Language Anglais
Journal information "Bioinformatics" - Vol. 28, no.3, p. 441-443 (2011)
Peer reviewed yes
Publisher Oxford University Press (OUP)
issn 1367-4803
e-issn 1460-2059
Publication status Publié
Affiliation UCL - SSH/ISP - Institut supérieur de philosophie
Links
  1. Ackmann Michael, Wiech Hans, Mandelkow Eckhard, Nonsaturable Binding Indicates Clustering of Tau on the Microtubule Surface in a Paired Helical Filament-like Conformation, 10.1074/jbc.m002590200
  2. Kikkawa M., Direct visualization of the microtubule lattice seam both in vitro and in vivo, 10.1083/jcb.127.6.1965
  3. Sandblad Linda, Busch Karl Emanuel, Tittmann Peter, Gross Heinz, Brunner Damian, Hoenger Andreas, The Schizosaccharomyces pombe EB1 Homolog Mal3p Binds and Stabilizes the Microtubule Lattice Seam, 10.1016/j.cell.2006.11.025
  4. Tsien Roger Y., THE GREEN FLUORESCENT PROTEIN, 10.1146/annurev.biochem.67.1.509
  5. Zhu Zhiqing C., Gupta Kamlesh K., Slabbekoorn Aranda R., Paulson Benjamin A., Folker Eric S., Goodson Holly V., Interactions between EB1 and Microtubules : DRAMATIC EFFECT OF AFFINITY TAGS AND EVIDENCE FOR COOPERATIVE BEHAVIOR, 10.1074/jbc.m109.013466
Bibliographic reference Philip, Julia T. ; Pence, Charles H. ; Goodson, Holly V.. MTBindingSim: simulate protein binding to microtubules. In: Bioinformatics, Vol. 28, no.3, p. 441-443 (2011)
Permanent URL http://hdl.handle.net/2078.1/202868