Amides de la dopamine avec les acides gras essentiels ou fondamentaux. Synthèse et étude pharmacologique.

Dopamine amides with palmitic, stearic and linoleic acid, their diacetates and carbonates were synthesized and their action on mice and rats was studied. The experimental results which are obtained from these derivatives (antagonized or non antagonized hypomotility by neuroleptics in low doses on mice, potentiation of the haloperidol catalepsy or not, on rats) could be compatible with a selective action of these amides on the autoreceptors of the cerebral dopaminergic neurons and with a preferential activity of some derivatives on certain cerebral areas (mesencephalon or striatum).