User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography

Primary tabs

download
  • Open access
  • PDF
  • 346.98 K
Sanders, Margreet F. van Doormaal, Pieter Jan Beeftink, Martine M. A. Bots, Michiel L. Fadl Elmula, Fadl Elmula M. Hammer, Frank [UCL] Persu, Alexandre [UCL] Renkin, Jean [UCL] European Network COordinating research on Renal Denervation (ENCOReD) Consortium

(eng) OBJECTIVES: Relatively little is known about the incidence of long-term renal damage after renal denervation (RDN), a potential new treatment for hypertension. In this study the incidence of renal artery and parenchymal changes, assessed with contrast-enhanced magnetic resonance angiography (MRA) after RDN, is investigated. METHODS: This study is an initiative of ENCOReD, a collaboration of hypertension expert centres. Patients in whom an MRA was performed before and after RDN were included. Scans were evaluated by two independent, blinded radiologists. Primary outcome was the change in renal artery morphology and parenchyma. RESULTS: MRAs from 96 patients were analysed. Before RDN, 41 renal anomalies were observed, of which 29 mostly mild renal artery stenoses. After a median time of 366 days post RDN, MRA showed a new stenosis (25-49% lumen reduction) in two patients and progression of pre-existing lumen reduction in a single patient. No other renal changes were observed and renal function remained stable. CONCLUSIONS: We observed new or progressed renal artery stenosis in three out of 96 patients, after a median time of 12 months post RDN (3.1%). Procedural angiographies showed that ablations were applied near the observed stenosis in only one of the three patients. KEY POINTS: • The incidence of vascular changes 12 months post RDN was 3.1%. • No renal vascular or parenchymal changes other than stenoses were observed. • Ablations were applied near the stenosis in only one of three patients.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "European Radiology" - Vol. 27, no. 9, p. 3934-3941 (2017)
Peer reviewed yes
Publisher Springer International ((Germany) Berlin)
issn 0938-7994
e-issn 1432-1084
Publication status Publié
Affiliations UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - (SLuc) Service de cardiologie
UCL - (SLuc) Service de radiologie
UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale
UCL - SSS/IONS/NEUR - Clinical Neuroscience
Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; Hypertension ; Magnetic resonance angiography ; Renal artery stenosis ; Renal denervation ; Vascular changes
Links
  1. Krum Henry, Schlaich Markus, Whitbourn Rob, Sobotka Paul A, Sadowski Jerzy, Bartus Krzysztof, Kapelak Boguslaw, Walton Anthony, Sievert Horst, Thambar Suku, Abraham William T, Esler Murray, Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study, 10.1016/s0140-6736(09)60566-3
  2. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial, 10.1016/s0140-6736(10)62039-9
  3. Blessing Erwin, Esler Murray D., Francis Darrel P., Schmieder Roland E., Cardiac Ablation and Renal Denervation Systems Have Distinct Purposes and Different Technical Requirements, 10.1016/j.jcin.2012.12.005
  4. Templin Christian, Jaguszewski Milosz, Ghadri Jelena R., Sudano Isabella, Gaehwiler Roman, Hellermann Jens P., Schoenenberger-Berzins Renate, Landmesser Ulf, Erne Paul, Noll Georg, Lüscher Thomas F., Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter, 10.1093/eurheartj/eht141
  5. Lambert T, Blessberger H, Grund M, Steinwender C (2014) Late renal artery stenosis after percutaneous renal denervation. J Cardiovasc Med (Hagerstown) 15
  6. Vonend Oliver, Antoch Gerald, Rump Lars Christian, Blondin Dirk, Secondary rise in blood pressure after renal denervation, 10.1016/s0140-6736(12)61145-3
  7. Kaltenbach Benjamin, Id Dani, Franke Jennifer C., Sievert Horst, Hennersdorf Marcus, Maier Jens, Bertog Stefan C., Renal Artery Stenosis After Renal Sympathetic Denervation, 10.1016/j.jacc.2012.09.027
  8. Persu Alexandre, Sapoval Marc, Azizi Michel, Monge Matthieu, Danse Etienne, Hammer Frank, Renkin Jean, Renal artery stenosis following renal denervation : a matter of concern, 10.1097/hjh.0000000000000323
  9. Bhamra-Ariza Paul, Rao Sriram, Muller David W, Renal artery stenosis following renal percutaneous denervation : Renal Artery Stenosis, 10.1002/ccd.25546
  10. Rosa J, Widimsky P, Waldauf P et al (2016) Role of adding spironolactone and renal denervation in true resistant hypertension: one-year outcomes of randomized PRAGUE-15 study. Hypertension 67:397–403
  11. Krum Henry, Schlaich Markus P, Sobotka Paul A, Böhm Michael, Mahfoud Felix, Rocha-Singh Krishna, Katholi Richard, Esler Murray D, Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study, 10.1016/s0140-6736(13)62192-3
  12. Bhatt Deepak L., Kandzari David E., O'Neill William W., D'Agostino Ralph, Flack John M., Katzen Barry T., Leon Martin B., Liu Minglei, Mauri Laura, Negoita Manuela, Cohen Sidney A., Oparil Suzanne, Rocha-Singh Krishna, Townsend Raymond R., Bakris George L., A Controlled Trial of Renal Denervation for Resistant Hypertension, 10.1056/nejmoa1402670
  13. Papademetriou V., Tsioufis C. P., Sinhal A., Chew D. P., Meredith I. T., Malaiapan Y., Worthley M. I., Worthley S. G., Catheter-Based Renal Denervation for Resistant Hypertension: 12-Month Results of the EnligHTN I First-in-Human Study Using a Multielectrode Ablation System, 10.1161/hypertensionaha.114.03605
  14. Zhang Zhi-Hui, Yang Kan, Jiang Feng-Lin, Zeng Li-Xiong, Jiang Wei-Hong, Wang Xiao-Yan, The Effects of Catheter-Based Radiofrequency Renal Denervation on Renal Function and Renal Artery Structure in Patients With Resistant Hypertension, 10.1111/jch.12367
  15. Mahfoud F., Cremers B., Janker J., Link B., Vonend O., Ukena C., Linz D., Schmieder R., Rump L. C., Kindermann I., Sobotka P. A., Krum H., Scheller B., Schlaich M., Laufs U., Bohm M., Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension, 10.1161/hypertensionaha.112.193870
  16. Lambert Thomas, Nahler Alexander, Reiter Christian, Schwarz Stefan, Gammer Verena, Blessberger Hermann, Kammler Jürgen, Saleh Karim, Grund Michael, Steinwender Clemens, Frequency of Renal Artery Stenosis After Renal Denervation in Patients With Resistant Arterial Hypertension, 10.1016/j.amjcard.2015.02.055
  17. Schmid Axel, Schmieder Raphael, Lell Michael, Janka Rolf, Veelken Roland, Schmieder Roland E., Uder Michael, Ott Christian, Mid-Term Vascular Safety of Renal Denervation Assessed by Follow-up MR Imaging, 10.1007/s00270-015-1192-2
  18. Esler M. D., Bohm M., Sievert H., Rump C. L., Schmieder R. E., Krum H., Mahfoud F., Schlaich M. P., Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial, 10.1093/eurheartj/ehu209
  19. Persu A., Jin Y., Baelen M., Vink E., Verloop W. L., Schmidt B., Blicher M. K., Severino F., Wuerzner G., Taylor A., Pechere-Bertschi A., Jokhaji F., Fadl Elmula F. E. M., Rosa J., Czarnecka D., Ehret G., Kahan T., Renkin J., Widimsky J., Jacobs L., Spiering W., Burnier M., Mark P. B., Menne J., Olsen M. H., Blankestijn P. J., Kjeldsen S., Bots M. L., Staessen J. A., , Eligibility for Renal Denervation: Experience at 11 European Expert Centers, 10.1161/hypertensionaha.114.03194
  20. Persu A, , Jin Y, Azizi M, Baelen M, Völz S, Elvan A, Severino F, Rosa J, Adiyaman A, Fadl Elmula F E, Taylor A, Pechère-Bertschi A, Wuerzner G, Jokhaji F, Kahan T, Renkin J, Monge M, Widimský P, Jacobs L, Burnier M, Mark P B, Kjeldsen S E, Andersson B, Sapoval M, Staessen J A, Blood pressure changes after renal denervation at 10 European expert centers, 10.1038/jhh.2013.88
  21. Vink E. E., Boer A., Verloop W. L., Spiering W., Voskuil M., Vonken E., Hoogduin J. M., Leiner T., Bots M. L., Blankestijn P. J., The effect of renal denervation on kidney oxygenation as determined by BOLD MRI in patients with hypertension, 10.1007/s00330-014-3583-1
  22. Sanders MF, Blankestijn PJ, Voskuil M et al (2016) Safety and long-term effects of renal denervation: rationale and design of the Dutch registry. Neth J Med 74:5–15
  23. Persu Alexandre, Azizi Michel, Jin Yu, Volz Sebastian, Rosa Jan, Fadl Elmula Fadl Elmula M., Pechere-Bertschi Antoinette, Burnier Michel, Mark Patrick B., Elvan Arif, Renkin Jean, Sapoval Marc, Kahan Thomas, Kjeldsen Sverre, Staessen Jan A., Hyperresponders vs. nonresponder patients after renal denervation : do they differ?, 10.1097/hjh.0000000000000347
  24. Fadl Elmula F. E. M., Hoffmann P., Larstorp A. C., Fossum E., Brekke M., Kjeldsen S. E., Gjonnaess E., Hjornholm U., Kjaer V. N., Rostrup M., Os I., Stenehjem A., Hoieggen A., Adjusted Drug Treatment Is Superior to Renal Sympathetic Denervation in Patients With True Treatment-Resistant Hypertension, 10.1161/hypertensionaha.114.03246
  25. Fadl Elmula F. E. M., Hoffmann P., Fossum E., Brekke M., Gjonnaess E., Hjornholm U., Kjaer V. N., Rostrup M., Kjeldsen S. E., Os I., Stenehjem A.-E., Hoieggen A., Renal Sympathetic Denervation in Patients With Treatment-Resistant Hypertension After Witnessed Intake of Medication Before Qualifying Ambulatory Blood Pressure, 10.1161/hypertensionaha.113.01452
  26. Levey Andrew S., Stevens Lesley A., Schmid Christopher H., Zhang Yaping (Lucy), Castro Alejandro F., Feldman Harold I., Kusek John W., Eggers Paul, Van Lente Frederick, Greene Tom, Coresh Josef, , A New Equation to Estimate Glomerular Filtration Rate, 10.7326/0003-4819-150-9-200905050-00006
  27. Mancia Giuseppe, Fagard Robert, Narkiewicz Krzysztof, Redón Josep, Zanchetti Alberto, Böhm Michael, Christiaens Thierry, Cifkova Renata, De Backer Guy, Dominiczak Anna, Galderisi Maurizio, Grobbee Diederick E., Jaarsma Tiny, Kirchhof Paulus, Kjeldsen Sverre E., Laurent Stéphane, Manolis Athanasios J., Nilsson Peter M., Ruilope Luis Miguel, Schmieder Roland E., Sirnes Per Anton, Sleight Peter, Viigimaa Margus, Waeber Bernard, Zannad Faiez, 2013 ESH/ESC Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC), 10.1097/01.hjh.0000431740.32696.cc
  28. Okada Takuya, Pellerin Olivier, Savard Sébastien, Curis Emmanuel, Monge Matthieu, Frank Michael, Bobrie Guillaume, Yamaguchi Masato, Sugimoto Koji, Plouin Pierre-François, Azizi Michel, Sapoval Marc, Eligibility for Renal Denervation: Anatomical Classification and Results in Essential Resistant Hypertension, 10.1007/s00270-014-0865-6
  29. Slanina Martin, Žižka Jan, Klzo Ludovít, Lojík Miroslav, Contrast-enhanced MR angiography utilizing parallel acquisition techniques in renal artery stenosis detection, 10.1016/j.ejrad.2009.07.010
  30. Rountas C., Vlychou M., Vassiou K., Liakopoulos V., Kapsalaki E., Koukoulis G., Fezoulidis I.V., Stefanidis I., Imaging Modalities for Renal Artery Stenosis in Suspected Renovascular Hypertension: Prospective Intraindividual Comparison of Color Doppler US, CT Angiography, GD-Enhanced MR Angiography, and Digital Substraction Angiography, 10.1080/08860220601166305
  31. Leiner T., de Haan M. W., Nelemans P. J., van Engelshoven J. M. A., Vasbinder G. B. C., Contemporary imaging techniques for the diagnosis of renal artery stenosis, 10.1007/s00330-005-2826-6
  32. Caps M. T., Perissinotto C., Zierler R. E., Polissar N. L., Bergelin R. O., Tullis M. J., Cantwell-Gab K., Davidson R. C., Strandness D. E., Prospective Study of Atherosclerotic Disease Progression in the Renal Artery, 10.1161/01.cir.98.25.2866
  33. Daugherty S. L., Powers J. D., Magid D. J., Tavel H. M., Masoudi F. A., Margolis K. L., O'Connor P. J., Selby J. V., Ho P. M., Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients, 10.1161/circulationaha.111.068064
  34. Wallace Jr Richard J., Nash Donald R., Steingrube Vincent A., Antibiotic susceptibilities and drug resistance in Moraxella (Branhamella) catarrhalis, 10.1016/0002-9343(90)90262-c
  35. Vink E. E., Goldschmeding R., Vink A., Weggemans C., Bleijs R. L. A. W., Blankestijn P. J., Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study, 10.1093/ndt/gfu192
  36. Tzafriri Abraham R., Keating John H., Markham Peter M., Spognardi Anna-Maria, L. Stanley James R., Wong Gee, Zani Brett G., Highsmith Debby, O’Fallon Patrick, Fuimaono Kristine, Mahfoud Felix, Edelman Elazer R., Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension, 10.1126/scitranslmed.aaa3236
Bibliographic reference Sanders, Margreet F. ; van Doormaal, Pieter Jan ; Beeftink, Martine M. A. ; Bots, Michiel L. ; Fadl Elmula, Fadl Elmula M. ; et. al. Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography. In: European Radiology, Vol. 27, no. 9, p. 3934-3941 (2017)
Permanent URL http://hdl.handle.net/2078.1/195292