User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress.

Primary tabs

download
  • Open access
  • PDF
  • 1.75 M
Page, Melissa [UCL] Sinclair A. Robb E.L. Stuart, JA. Withers, DJ. Selman, C.

Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be important. We have previously demonstrated that mice globally lacking insulin receptor substrate 1 (Irs1−/−) are long-lived and enjoy a greater period of their life free from age-related pathology compared with wild-type (WT) controls. In this study, we show that primary dermal fibroblasts and primary myoblasts derived from Irs1−/− mice are no more resistant to a range of oxidant and nonoxidant chemical stressors than cells derived from WT mice.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2014
Language Anglais
Journal information "Aging Cell" - Vol. 13, p. 962-964
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 1474-9718
e-issn 1474-9726
Publication status Publié
Affiliation University of Aberdeen, U.K. - Institute of Biology and Environmental Sicences
Keywords aging ; IRSI ; NRF2 ; oxidative stress ; stress resistance
Links
  1. Bokov Alex F., Lindsey Merry L., Khodr Christina, Sabia Marian R., Richardson Arlan, Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors, 10.1093/gerona/glp052
  2. Bokov Alex F., Garg Neha, Ikeno Yuji, Thakur Sachin, Musi Nicolas, DeFronzo Ralph A., Zhang Ning, Erickson Rebecca C., Gelfond Jon, Hubbard Gene B., Adamo Martin L., Richardson Arlan, Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?, 10.1371/journal.pone.0026891
  3. Clancy D. J., Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein, 10.1126/science.1057991
  4. Gems David, Partridge Linda, Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts, 10.1146/annurev-physiol-030212-183712
  5. Harper James M., Salmon Adam B., Chang Yayi, Bonkowski Michael, Bartke Andrzej, Miller Richard A., Stress resistance and aging: Influence of genes and nutrition, 10.1016/j.mad.2006.04.002
  6. Harper James M., Salmon Adam B., Leiser Scott F., Galecki Andrzej T., Miller Richard A., Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone, 10.1111/j.1474-9726.2006.00255.x
  7. Harper J. M., Wang M., Galecki A. T., Ro J., Williams J. B., Miller R. A., Fibroblasts from long-lived bird species are resistant to multiple forms of stress, 10.1242/jeb.054643
  8. Holzenberger Martin, Dupont Joëlle, Ducos Bertrand, Leneuve Patricia, Géloën Alain, Even Patrick C., Cervera Pascale, Le Bouc Yves, IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice, 10.1038/nature01298
  9. Kapahi Pankaj, Boulton Michael E, Kirkwood Thomas B.L, Positive correlation between mammalian life span and cellular resistance to stress, 10.1016/s0891-5849(98)00323-2
  10. Kappeler Laurent, Filho Carlos De Magalhaes, Dupont Joëlle, Leneuve Patricia, Cervera Pascale, Périn Laurence, Loudes Catherine, Blaise Annick, Klein Rüdiger, Epelbaum Jacques, Bouc Yves Le, Holzenberger Martin, Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism, 10.1371/journal.pbio.0060254
  11. Leiser S. F., Miller R. A., Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice, 10.1128/mcb.01145-09
  12. Miller R. A., Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms, 10.1093/gerona/gln072
  13. Murakami, FASEB J., 17, 1565 (2003)
  14. Panici J. A., Harper J. M., Miller R. A., Bartke A., Spong A., Masternak M. M., Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice, 10.1096/fj.10-163253
  15. Rojanathammanee, J. Gerontol. A Biol. Sci. Med. Sci. (2013)
  16. Salmon Adam B., Murakami Shin, Bartke Andrzej, Kopchick John, Yasumura Kyoko, Miller Richard A., Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress, 10.1152/ajpendo.00575.2004
  17. Selman C., Lingard S., Choudhury A. I., Batterham R. L., Claret M., Clements M., Ramadani F., Okkenhaug K., Schuster E., Blanc E., Piper M. D., Al-Qassab H., Speakman J. R., Carmignac D., Robinson I. C. A., Thornton J. M., Gems D., Partridge L., Withers D. J., Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice, 10.1096/fj.07-9261com
  18. Selman Colin, Partridge Linda, Withers Dominic J., Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1, 10.1371/journal.pone.0016144
  19. Wang Min, Miller Richard A., Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress : Increased autophagy in Snell dwarf fibroblasts, 10.1111/j.1474-9726.2012.00833.x
Bibliographic reference Page, Melissa ; Sinclair A. ; Robb E.L. ; Stuart, JA. ; Withers, DJ. ; et. al. Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress.. In: Aging Cell, Vol. 13, p. 962-964
Permanent URL http://hdl.handle.net/2078/192988