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The neural basis of perceived intensity in natural and artificial touch.

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Graczyk, Emily L Schiefer, Matthew A Saal, Hannes P Delhaye, Benoit [UCL] Bensmaia, Sliman J Tyler, Dustin J

Electrical stimulation of sensory nerves is a powerful tool for studying neural coding because it can activate neural populations in ways that natural stimulation cannot. Electrical stimulation of the nerve has also been used to restore sensation to patients who have suffered the loss of a limb. We have used long-term implanted electrical interfaces to elucidate the neural basis of perceived intensity in the sense of touch. To this end, we assessed the sensory correlates of neural firing rate and neuronal population recruitment independently by varying two parameters of nerve stimulation: pulse frequency and pulse width. Specifically, two amputees, chronically implanted with peripheral nerve electrodes, performed each of three psychophysical tasks-intensity discrimination, magnitude scaling, and intensity matching-in response to electrical stimulation of their somatosensory nerves. We found that stimulation pulse width and pulse frequency had systematic, cooperative effects on perceived tactile intensity and that the artificial tactile sensations could be reliably matched to skin indentations on the intact limb. We identified a quantity we termed the activation charge rate (ACR), derived from stimulation parameters, that predicted the magnitude of artificial tactile percepts across all testing conditions. On the basis of principles of nerve fiber recruitment, the ACR represents the total population spike count in the activated neural population. Our findings support the hypothesis that population spike count drives the magnitude of tactile percepts and indicate that sensory magnitude can be manipulated systematically by varying a single stimulation quantity.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2016
Language Anglais
Journal information "Science Translational Medicine" - Vol. 8, no. 362, p. 362ra142 [1-23] (2016)
Peer reviewed yes
Publisher American Association for the Advancement of Science ((United States) Washington, DC)
issn 1946-6234
e-issn 1946-6242
Publication status Publié
Affiliations University of Chicago - Organismal Biology and Anatomy
UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique
Links
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Bibliographic reference Graczyk, Emily L ; Schiefer, Matthew A ; Saal, Hannes P ; Delhaye, Benoit ; Bensmaia, Sliman J ; et. al. The neural basis of perceived intensity in natural and artificial touch.. In: Science Translational Medicine, Vol. 8, no. 362, p. 362ra142 [1-23] (2016)
Permanent URL http://hdl.handle.net/2078/191738