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Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report.

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Cingi, Cemal Gevaert, Philippe Mösges, Ralf Rondon, Carmen Hox, Valérie [UCL] Hupin, Cloé [UCL] Rombaux, Philippe [UCL] Bousquet, Jean

This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects. This report provides up-to-date usable information to: (1) improve the knowledge and skills of allergists, so as to ultimately improve the overall quality of patient care; (2) to increase interest in this area; and (3) to present a unique contribution to the field of upper inflammatory disease.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "Clinical and Translational Allergy" - Vol. 7, p. 17 [1-12] (2017)
Peer reviewed yes
Publisher BioMed Central Ltd. ((United Kingdom) London)
issn 2045-7022
e-issn 2045-7022
Publication status Publié
Affiliations UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service d'oto-rhino-laryngologie
Keywords Adenoid hypertrophy ; Allergic rhinitis (AR) ; Asthma ; Chronic middle ear effusions ; Comorbidities ; Conjunctivitis ; Disordered sleep ; Eczema ; Eosinophilic oesophagitis (EoE) ; Food allergies ; Obstructive sleep apnea ; Olfaction disorders ; Rhinitis ; Rhinosinusitis
Links
  1. Sih Tania, Mion Olavo, Allergic rhinitis in the child and associated comorbidities, 10.1111/j.1399-3038.2009.00933.x
  2. Scadding G. K., Bousquet J., Introduction, 10.1111/j.1398-9995.2007.01546.x
  3. Roberts G, Xatzipsalti M, Borrego LM, Custovic A, Halken S, Hellings PW, et al. Paediatric rhinitis: position paper of the European academy of allergy and clinical immunology. Allergy. 2013;68:1102–16.
  4. Comorbidity [Internet]. Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Comorbidity . Accessed 2 Dec 2013.
  5. Lack Gideon, Pediatric allergic rhinitis and comorbid disorders, 10.1067/mai.2001.115562
  6. Pinart Mariona, Benet Marta, Annesi-Maesano Isabella, von Berg Andrea, Berdel Dietrich, Carlsen Karin C L, Carlsen Kai-Håkon, Bindslev-Jensen Carsten, Eller Esben, Fantini Maria P, Lenzi Jacopo, Gehring Ulrike, Heinrich Joachim, Hohmann Cynthia, Just Jocelyne, Keil Thomas, Kerkhof Marjan, Kogevinas Manolis, Koletzko Sibylle, Koppelman Gerard H, Kull Inger, Lau Susanne, Melén Erik, Momas Isabelle, Porta Daniela, Postma Dirkje S, Rancière Fanny, Smit Henriette A, Stein Renato T, Tischer Christina G, Torrent Maties, Wickman Magnus, Wijga Alet H, Bousquet Jean, Sunyer Jordi, Basagaña Xavier, Guerra Stefano, Garcia-Aymerich Judith, Antó Josep M, Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study, 10.1016/s2213-2600(13)70277-7
  7. JanForum Feedback, 10.1046/j.1365-2648.1998.00442.x
  8. Bousquet Jean, van Cauwenberge Paul, Khaltaev Nikolai, Allergic Rhinitis and Its Impact on Asthma, 10.1067/mai.2001.118891
  9. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European Position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl. 2012;23:3 p (preceding table of contents, 1-298).
  10. Gaga M, Frew AJ, Varney VA, Kay AB. Eosinophil activation and T lymphocyte infiltration in allergen-induced late phase skin reactions and classical delayed-type hypersensitivity. J Immunol. 1991;147:816–22.
  11. Katelaris C. H., Linneberg A., Magnan A., Thomas W. R., Wardlaw A. J., Wark P., Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy : Year in review, 10.1111/j.1365-2222.2011.03892.x
  12. Ciprandi G, Pronzato C, Ricca V, Passalacqua G, Bagnasco M, Canonica G W, Allergen-specific challenge induces intercellular adhesion molecule 1 (ICAM-1 or CD54) on nasal epithelial cells in allergic subjects. Relationships with early and late inflammatory phenomena., 10.1164/ajrccm.150.6.7524984
  13. Braunstahl G.-J., United Airways Concept: What Does it Teach Us about Systemic Inflammation in Airways Disease?, 10.1513/pats.200906-052dp
  14. Shaaban Rafea, Zureik Mahmoud, Soussan David, Neukirch Catherine, Heinrich Joachim, Sunyer Jordi, Wjst Matthias, Cerveri Isa, Pin Isabelle, Bousquet Jean, Jarvis Deborah, Burney Peter G, Neukirch Françoise, Leynaert Bénédicte, Rhinitis and onset of asthma: a longitudinal population-based study, 10.1016/s0140-6736(08)61446-4
  15. Clatworthy Jane, Price David, Ryan Dermot, Haughney John, Horne Rob, The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control, 10.4104/pcrj.2009.00037
  16. Ciprandi Giorgio, Cirillo Ignazio, Signori Alessio, Impact of allergic rhinitis on bronchi: An 8-year follow-up study, 10.2500/ajra.2011.25.3607
  17. Navarro A, Valero A, Juliá B, Quirce S. Coexistence of asthma and allergic rhinitis in adult patients attending allergy clinics: ONEAIR study. J Investig Allergol Clin Immunol. 2008;18:233–8.
  18. Ko FW, Ip MS, Chu CM, So LK, Lam DC, Hui DS. Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: a multicentre study. Hong Kong Med J. 2010;16:354–61.
  19. Valero A, Pereira C, Loureiro C, Martínez-Cócera C, Murio C, Rico P, et al. Interrelationship between skin sensitization, rhinitis, and asthma in patients with allergic rhinitis: a study of Spain and Portugal. J Investig Allergol Clin Immunol. 2009;19:167–72.
  20. Mölter A, Simpson A, Berdel D, Brunekreef B, Custovic A, Cyrys J, et al. A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project. Eur Respir J 2014. [Epub ahead of print].
  21. Lee Chih-Hung, Chuang Hung-Yi, Shih Chia-Chi, Jee Shiou-Hwa, Wang Li-Fang, Chiu Hsien-Ching, Chang Chung-Hsing, Wu Chieh-Shan, Yu Hsin-Su, Correlation of Serum Total IgE, Eosinophil Granule Cationic Proteins, Sensitized Allergens and Family Aggregation in Atopic Dermatitis Patients with or without Rhinitis, 10.1111/j.1346-8138.2004.tb00600.x
  22. Lugović L, Lipozencić J. Are respiratory allergic diseases related to atopic dermatitis? Coll Antropol. 2000;24:335–45.
  23. Sole Dirceu, Camelo-Nunes Ines C., Wandalsen Gustavo F., Melo Karyn C., Naspitz Charles K., Is rhinitis alone or associated with atopic eczema a risk factor for severe asthma in children?, 10.1111/j.1399-3038.2005.00227.x
  24. Silverberg Jonathan I., Simpson Eric L., Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization, 10.1111/pai.12095
  25. Umeki Shigenobu, Allergic Cycle: Relationships Between Asthma Allergic Rhinitis, and Atopic Dermatitis, 10.3109/02770909409056765
  26. Popescu F-D. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015;26(5):31–50. doi: 10.5662/wjm.v5.i2.31 .
  27. Caliskaner Z., Naiboglu B., Kutlu A., Kartal O., Ozturk S., Onem Y., Erkan M., Gulec M., Colak C., Sener O., Risk factors for oral allergy syndrome in patients with seasonal allergic rhinitis, 10.4317/medoral.16.e312
  28. ASERO R, MASSIRONI F, VELATI C, Detection of prognostic factors for oral allergy syndrome in patients with birch pollen hypersensitivity, 10.1016/s0091-6749(96)70306-8
  29. Skypala I. J., Calderon M. A., Leeds A. R., Emery P., Till S.J, Durham S. R., Development and validation of a structured questionnaire for the diagnosis of oral allergy syndrome in subjects with seasonal allergic rhinitis during the UK birch pollen season : Validation of OAS diagnostic questionnaire, 10.1111/j.1365-2222.2011.03759.x
  30. Dondi Arianna, Tripodi Salvatore, Panetta Valentina, Asero Riccardo, Businco Andrea Di Rienzo, Bianchi Annamaria, Carlucci Antonio, Ricci Giampaolo, Bellini Federica, Maiello Nunzia, Miraglia del Giudice Michele, Frediani Tullio, Sodano Simona, Dello Iacono Iride, Macrì Francesco, Massaccesi Valerio, Caffarelli Carlo, Rinaldi Laura, Patria Maria Francesca, Varin Elena, Peroni Diego, Chinellato Iolanda, Chini Loredana, Moschese Viviana, Lucarelli Sandra, Bernardini Roberto, Pingitore Giuseppe, Pelosi Umberto, Tosca Mariangela, Paravati Francesco, La Grutta Stefania, Meglio Paolo, Calvani Mauro, Plebani Mario, Matricardi Paolo Maria, , Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity, 10.1111/pai.12136
  31. Kusunoki Takashi, Mukaida Kumiko, Morimoto Takeshi, Sakuma Mio, Yasumi Takahiro, Nishikomori Ryuta, Heike Toshio, Birth order effect on childhood food allergy : Birth order effect on childhood food allergy, 10.1111/j.1399-3038.2011.01246.x
  32. Pongdee T. Pollen food syndrome (PFS). The American Academy of Allergy, Asthma & Immunology (AAAAI). https://www.aaaai.org/conditions-and-treatments/library/allergy-library/outdoor-allergies-and-food-allergies-can-be-relate . Accessed 30 Mar 2017.
  33. Czarnecka-Operacz M, Jenerowicz D, Silny W. Oral allergy syndrome in patients with airborne pollen allergy treated with specific immunotherapy. Acta Dermatovenerol Croat. 2008;16:19–24.
  34. NELSON H, LAHR J, RULE R, BOCK A, LEUNG D, Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract1, 10.1016/s0091-6749(97)80006-1
  35. Reisacher William R., Davison Wesley, Immunotherapy for food allergy : , 10.1097/moo.0000000000000353
  36. Mauro Marina, Russello Marina, Incorvaia Cristoforo, Gazzola Gianbattista, Frati Franco, Moingeon Philippe, Passalacqua Gianni, Birch-Apple Syndrome Treated with Birch Pollen Immunotherapy, 10.1159/000323909
  37. Liacouras Chris A., Furuta Glenn T., Hirano Ikuo, Atkins Dan, Attwood Stephen E., Bonis Peter A., Burks A. Wesley, Chehade Mirna, Collins Margaret H., Dellon Evan S., Dohil Ranjan, Falk Gary W., Gonsalves Nirmala, Gupta Sandeep K., Katzka David A., Lucendo Alfredo J., Markowitz Jonathan E., Noel Richard J., Odze Robert D., Putnam Philip E., Richter Joel E., Romero Yvonne, Ruchelli Eduardo, Sampson Hugh A., Schoepfer Alain, Shaheen Nicholas J., Sicherer Scott H., Spechler Stuart, Spergel Jonathan M., Straumann Alex, Wershil Barry K., Rothenberg Marc E., Aceves Seema S., Eosinophilic esophagitis: Updated consensus recommendations for children and adults, 10.1016/j.jaci.2011.02.040
  38. Dellon Evan S, Gonsalves Nirmala, Hirano Ikuo, Furuta Glenn T, Liacouras Chris A, Katzka David A, ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE), 10.1038/ajg.2013.71
  39. Furuta Glenn T., Liacouras Chris A., Collins Margaret H., Gupta Sandeep K., Justinich Chris, Putnam Phil E., Bonis Peter, Hassall Eric, Straumann Alex, Rothenberg Marc E., Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment, 10.1053/j.gastro.2007.08.017
  40. Prasad Ganapathy A., Talley Nicholas J., Romero Yvonne, Arora Amindra S., Kryzer Lori A., Smyrk Thomas C., Alexander Jeffery A., Prevalence and Predictive Factors of Eosinophilic Esophagitis in Patients Presenting With Dysphagia: A Prospective Study, 10.1111/j.1572-0241.2007.01512.x
  41. MACKENZIE S. H., GO M., CHADWICK B., THOMAS K., FANG J., KUWADA S., LAMPHIER S., HILDEN K., PETERSON K., Eosinophilic oesophagitis in patients presenting with dysphagia - a prospective analysis, 10.1111/j.1365-2036.2008.03795.x
  42. Desai Tusar K., Stecevic Veslav, Chang Chung-Ho, Goldstein Neal S., Badizadegan Kamran, Furuta Glenn T., Association of eosinophilic inflammation with esophageal food impaction in adults, 10.1016/s0016-5107(05)00313-5
  43. Fass Ronnie, Gasiorowska Anita, Refractory GERD: What is it?, 10.1007/s11894-008-0052-5
  44. Bomis PAL, Furuta GT. Treatment of eosinophilic esophagitis. In: Talley NJ, Grover S, editors. UpToDate. https://www.uptodate.com/contents/treatment-of-eosinophilic-esophagitis#H209980 . Accessed 31 Mar 2017.
  45. Peterson Kathryn A., Thomas Kristen L., Hilden Kristen, Emerson Lyska L., Wills Jason C., Fang John C., Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis, 10.1007/s10620-009-0859-4
  46. Schoepfer Alain M, Gonsalves Nirmala, Bussmann Christian, Conus Sébastien, Simon Hans-Uwe, Straumann Alex, Hirano Ikuo, Esophageal Dilation in Eosinophilic Esophagitis: Effectiveness, Safety, and Impact on the Underlying Inflammation, 10.1038/ajg.2009.657
  47. Robles-Medranda C, Villard F, le Gall C, et al. Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? J Pediatr Gastroenterol Nutr. 2010;50:516.
  48. Straumann A., Hoesli S., Bussmann Ch., Stuck M., Perkins M., Collins L. P., Payton M., Pettipher R., Hunter M., Steiner J., Simon H.-U., Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis, 10.1111/all.12096
  49. Attwood S E A, Eosinophilic oesophagitis: a novel treatment using Montelukast, 10.1136/gut.52.2.181
  50. Straumann A, Conus S, Grzonka P, Kita H, Kephart G, Bussmann C, Beglinger C, Smith D A, Patel J, Byrne M, Simon H-U, Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial, 10.1136/gut.2009.178558
  51. Netzer Peter, Gschossmann Juergen M., Straumann Alex, Sendensky Alexander, Weimann Rosemarie, Schoepfer Alain M., Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission : , 10.1097/meg.0b013e32825a6ab4
  52. Bonini S, Coassin M, Aronni S, Lambiase A, Vernal keratoconjunctivitis, 10.1038/sj.eye.6700675
  53. Pitt Andrew D., Smith Andrew F., Lindsell Lynda, Voon Li Wern, Rose Peter W., Bron Anthony J., Economic and quality-of-life impact of seasonal allergic conjunctivitis in Oxfordshire, 10.1076/opep.11.1.17.26437
  54. O'Meara T. J., Sercombe J. K., Morgan G., Reddel H. K., Xuan W., Tovey E. R., The reduction of rhinitis symptoms by nasal filters during natural exposure to ragweed and grass pollen, 10.1111/j.1398-9995.2005.00741.x
  55. Keith Paul K., Scadding Glenis K., Are intranasal corticosteroids all equally consistent in managing ocular symptoms of seasonal allergic rhinitis?, 10.1185/03007990903094106
  56. Azelastine/fluticasone propionate (Dymista) for seasonal allergic rhinitis. Med Lett Drugs Ther. 2012; 54:85–7.
  57. Williams, Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis, 10.2147/opth.s13479
  58. RACHELEFSKY G, GOLDBERG M, KATZ R, BORIS G, GYEPES M, SHAPIRO M, MICKEY M, FINEGOLD S, SIEGEL S, Sinus disease in children with respiratory allergy, 10.1016/0091-6749(78)90052-0
  59. Scadding G.K, Recent advances in the treatment of rhinitis and rhinosinusitis, 10.1016/j.ijporl.2003.08.026
  60. Sedaghat Ahmad R., Phipatanakul Wanda, Cunningham Michael J., Atopy and the development of chronic rhinosinusitis in children with allergic rhinitis, 10.1016/j.jaip.2013.07.012
  61. Hellings P. W., Fokkens W. J., Allergic rhinitis and its impact on otorhinolaryngology, 10.1111/j.1398-9995.2006.01109.x
  62. Bachert Claus, Zhang Nan, Holtappels Gabriele, De Lobel Lizzy, van Cauwenberge Paul, Liu Shixi, Lin Ping, Bousquet Jean, Van Steen Kristel, Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma, 10.1016/j.jaci.2010.07.007
  63. SETTIPANE G, CHAFEE F, Nasal polyps in asthma and rhinitis A review of 6,037 patients, 10.1016/0091-6749(77)90171-3
  64. PANG YOKE-TEEN, ESKICI ORHAN, WILSON JANET A., Nasal polyposis: Role of subclinical delayed food hypersensitivity☆☆☆, 10.1016/s0194-5998(00)70259-2
  65. Gevaert P., Holtappels G., Johansson S. G. O., Cuvelier C., Cauwenberge P., Bachert C., Organization of secondary lymphoid tissue and local IgE formation toStaphylococcus aureusenterotoxins in nasal polyp tissue, 10.1111/j.1398-9995.2004.00621.x
  66. Gevaert P., Nouri-Aria K. T., Wu H., Harper C. E., Takhar P., Fear D. J., Acke F., De Ruyck N., Banfield G., Kariyawasam H. H., Bachert C., Durham S. R., Gould H. J., Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps, 10.1111/all.12054
  67. Van Zele T., Gevaert P., Holtappels G., van Cauwenberge P., Bachert C., Local immunoglobulin production in nasal polyposis is modulated by superantigens, 10.1111/j.1365-2222.2007.02838.x
  68. Bachert Claus, Gevaert Philippe, Holtappels Gabriele, Johansson S.G.O., van Cauwenberge Paul, Total and specific IgE in nasal polyps is related to local eosinophilic inflammation, 10.1067/mai.2001.112374
  69. Gevaert Philippe, Calus Lien, Van Zele Thibaut, Blomme Katrien, De Ruyck Natalie, Bauters Wouter, Hellings Peter, Brusselle Guy, De Bacquer Dirk, van Cauwenberge Paul, Bachert Claus, Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma, 10.1016/j.jaci.2012.07.047
  70. Parikh A, Alles R, Hawk L, Pringle M, Darby Y, Scadding GK. Treatment of allergic rhinitis and its impact in children with chronic otitis media with effusion. J Audiol Med. 2000;9:104–17.
  71. Umapathy Dolores, Alles Roshini, Scadding Glenis K., A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school children, 10.1016/j.ijporl.2006.12.017
  72. Nguyen Lily H.P., Manoukian John J., Sobol Steven E., Tewfik Ted L., Mazer Bruce D., Schloss Melvin D., Taha Rame, Hamid Qutayba A., Similar allergic inflammation in the middle ear and the upper airway: Evidence linking otitis media with effusion to the united airways concept, 10.1016/j.jaci.2004.07.061
  73. Bousquet J., Khaltaev N., Cruz A. A., Denburg J., Fokkens W. J., Togias A., Zuberbier T., Baena-Cagnani C. E., Canonica G. W., Van Weel C., Agache I., Aït-Khaled N., Bachert C., Blaiss M. S., Bonini S., Boulet L.-P., Bousquet P.-J., Camargos P., Carlsen K.-H., Chen Y., Custovic A., Dahl R., Demoly P., Douagui H., Durham S. R., Van Wijk R. Gerth, Kalayci O., Kaliner M. A., Kim Y.-Y., Kowalski M. L., Kuna P., Le L. T. T., Lemiere C., Li J., Lockey R. F., Mavale-Manuel S., Meltzer E. O., Mohammad Y., Mullol J., Naclerio R., O’Hehir R. E., Ohta K., Ouedraogo S., Palkonen S., Papadopoulos N., Passalacqua G., Pawankar R., Popov T. A., Rabe K. F., Rosado-Pinto J., Scadding G. K., Simons F. E. R., Toskala E., Valovirta E., Van Cauwenberge P., Wang D.-Y., Wickman M., Yawn B. P., Yorgancioglu A., Yusuf O. M., Zar H., Annesi-Maesano I., Bateman E. D., Kheder A. Ben, Boakye D. A., Bouchard J., Burney P., Busse W. W., Chan-Yeung M., Chavannes N. H., Chuchalin A., Dolen W. K., Emuzyte R., Grouse L., Humbert M., Jackson C., Johnston S. L., Keith P. K., Kemp J. P., Klossek J.-M., Larenas-Linnemann D., Lipworth B., Malo J.-L., Marshall G. D., Naspitz C., Nekam K., Niggemann B., Nizankowska-Mogilnicka E., Okamoto Y., Orru M. P., Potter P., Price D., Stoloff S. W., Vandenplas O., Viegi G., Williams D., Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* : ARIA: 2008 Update, 10.1111/j.1398-9995.2007.01620.x
  74. Klemola T. Deficiency of immunoglobulin A. Ann Clin Res. 1987;19(4):248–57.
  75. Aghamohammadi Asghar, Cheraghi Taher, Gharagozlou Mohammad, Movahedi Masoud, Rezaei Nima, Yeganeh Mehdi, Parvaneh Nima, Abolhassani Hassan, Pourpak Zahra, Moin Mostafa, IgA Deficiency: Correlation Between Clinical and Immunological Phenotypes, 10.1007/s10875-008-9229-9
  76. Caffarelli, Savini, Giordano, Gianlupi, Cavagni, Atopy in children with otitis media with effusion, 10.1046/j.1365-2222.1998.00284.x
  77. Griffin GH, Flynn C, Bailey RE, Schultz JK. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev. 2006;4:CD003423.
  78. Scadding GK, Darby YC, Jansz AJ, Richards D, Tate H, Hills S, et al. Double-blind, placebo controlled randomised trial of medical therapy in otitis media with effusion. Adv Life Sci Health. 2014;1:58–68.
  79. Criscuoli G., D'Amora S., Ripa G., Cinquegrana G., Mansi N., Impagliazzo N., Pisacane A., Frequency of Surgery Among Children Who Have Adenotonsillar Hypertrophy and Improve After Treatment With Nasal Beclomethasone, 10.1542/peds.111.3.e236
  80. Huang Shih-Wen, Giannoni Carla, The risk of adenoid hypertrophy in children with allergic rhinitis, 10.1016/s1081-1206(10)62251-x
  81. Scadding Glenis, Non-surgical treatment of adenoidal hypertrophy: The role of treating IgE-mediated inflammation : Inflammation in adenoidal hypertrophy, 10.1111/j.1399-3038.2010.01012.x
  82. Guss Joel, Doghramji Laurel, Reger Christine, Chiu Alexander G., Olfactory Dysfunction in Allergic Rhinitis, 10.1159/000242429
  83. KLIMEK L, EGGERS G, Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation, 10.1016/s0091-6749(97)70218-5
  84. Fonteyn S., Huart C., Deggouj N., Collet S., Eloy P., Rombaux P., Non-sinonasal-related olfactory dysfunction: A cohort of 496 patients, 10.1016/j.anorl.2013.03.006
  85. Doerfler H., Hummel T., Klimek L., Kobal G., Intranasal trigeminal sensitivity in subjects with allergic rhinitis, 10.1007/s00405-005-0954-x
  86. Fleiner Franca, Goktas Onder, Topical Beclomethasone in the Therapy of Smelling Disorders—A New Application Technique, 10.1007/s12070-010-0063-z
  87. Stuck B. A., Blum A., Hagner A. E., Hummel T., Klimek L., Hormann K., Mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis, 10.1034/j.1398-9995.2003.00162.x
  88. Guilemany José Maria, García-Piñero Alfons, Alobid Isam, Centellas Silvia, Mariño Franklin Santiago, Valero Antonio, Bernal-Sprekelsen Manuel, Picado César, Mullol Joaquim, The Loss of Smell in Persistent Allergic Rhinitis Is Improved by Levocetirizine due to Reduction of Nasal Inflammation but Not Nasal Congestion (the CIRANO Study), 10.1159/000331329
  89. Rank Matthew A., Kelkar Pramod, Oppenheimer John J., Taming chronic cough, 10.1016/s1081-1206(10)60875-7
  90. Verguts Monique M. L., Eggermont Anita, Decoster Wivine, de Jong Felix I. C. R. S., Hellings Peter W., Laryngeal effects of nasal allergen provocation in singers with allergic rhinitis, 10.1007/s00405-010-1420-y
  91. DelGaudio John M., Steroid Inhaler Laryngitis : Dysphonia Caused by Inhaled Fluticasone Therapy, 10.1001/archotol.128.6.677
  92. THEODOROPOULOS DEMETRIOS S., LEDFORD DENNIS K., LOCKEY RICHARD F., PECORARO DONNA L., RODRIGUEZ JOHN A., JOHNSON MILTON C., BOYCE H. WORTH, Prevalence of Upper Respiratory Symptoms in Patients with Symptomatic Gastroesophageal Reflux Disease, 10.1164/ajrccm.164.1.2006002
  93. Canonica G. W., Bousquet J., Mullol J., Scadding G. K., Virchow J. C., A survey of the burden of allergic rhinitis in Europe, 10.1111/j.1398-9995.2007.01549.x
  94. Léger Damien, Allergic Rhinitis and Its Consequences on Quality of Sleep : An Unexplored Area, 10.1001/archinte.166.16.1744
  95. Craig Timothy J., Teets Stephanie, Lehman Erik B., Chinchilli Vernon M., Zwillich Clifford, Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids☆☆☆★★★, 10.1016/s0091-6749(98)70171-x
  96. Simons F. Estelle R., Learning Impairment and Allergic Rhinitis, 10.2500/108854196778996895
  97. Baraniuk James N, Clauw Daniel J, Gaumond Ethan, Rhinitis Symptoms in Chronic Fatigue Syndrome, 10.1016/s1081-1206(10)63129-8
  98. Vuurman E. F. P. M., Vuurman L. L., Lutgens I., Kremer B., Allergic rhinitis is a risk factor for traffic safety, 10.1111/all.12418
  99. Walker Samantha, Khan-Wasti Saba, Fletcher Monica, Cullinan Paul, Harris Jessica, Sheikh Aziz, Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: Case-control study, 10.1016/j.jaci.2007.03.034
  100. Chhabra Nipun, Houser Steven M., Surgery for allergic rhinitis : Surgery for allergic rhinitis, 10.1002/alr.21387
  101. Allergic rhinitis University of Maryland Medical Center. http://umm.edu/health/medical/reports/articles/allergic-rhinitis . Accessed 30 July 2015.
  102. Jose J, Coatesworth AP. Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment. Cochrane Database Syst Rev. 2010;12:CD005235.
  103. Chhabra Nipun, Houser Steven M., The Surgical Management of Allergic Rhinitis, 10.1016/j.otc.2011.03.007
  104. Bousquet J., Schünemann H.J., Samolinski B., Demoly P., Baena-Cagnani C.E., Bachert C., Bonini S., Boulet L.P., Bousquet P.J., Brozek J.L., Canonica G.W., Casale T.B., Cruz A.A., Fokkens W.J., Fonseca J.A., van Wijk R. Gerth, Grouse L., Haahtela T., Khaltaev N., Kuna P., Lockey R.F., Lodrup Carlsen K.C., Mullol J., Naclerio R., O'Hehir R.E., Ohta K., Palkonen S., Papadopoulos N.G., Passalacqua G., Pawankar R., Price D., Ryan D., Simons F.E.R., Togias A., Williams D., Yorgancioglu A., Yusuf O.M., Aberer W., Adachi M., Agache I., Aït-Khaled N., Akdis C.A., Andrianarisoa A., Annesi-Maesano I., Ansotegui I.J., Baiardini I., Bateman E.D., Bedbrook A., Beghé B., Beji M., Bel E.H., Ben Kheder A., Bennoor K.S., Bergmann K.C., Berrissoul F., Bieber T., Bindslev Jensen C., Blaiss M.S., Boner A.L., Bouchard J., Braido F., Brightling C.E., Bush A., Caballero F., Calderon M.A., Calvo M.A., Camargos P.A.M., Caraballo L.R., Carlsen K.H., Carr W., Cepeda A.M., Cesario A., Chavannes N.H., Chen Y.Z., Chiriac A.M., Chivato Pérez T., Chkhartishvili E., Ciprandi G., Costa D.J., Cox L., Custovic A., Dahl R., Darsow U., De Blay F., Deleanu D., Denburg J.A., Devillier P., Didi T., Dokic D., Dolen W.K., Douagui H., Dubakiene R., Durham S.R., Dykewicz M.S., El-Gamal Y., El-Meziane A., Emuzyte R., Fiocchi A., Fletcher M., Fukuda T., Gamkrelidze A., Gereda J.E., González Diaz S., Gotua M., Guzmán M.A., Hellings P.W., Hellquist-Dahl B., Horak F., Hourihane J.O'B., Howarth P., Humbert M., Ivancevich J.C., Jackson C., Just J., Kalayci O., Kaliner M.A., Kalyoncu A.F., Keil T., Keith P.K., Khayat G., Kim Y.Y., Koffi N'Goran B., Koppelman G.H., Kowalski M.L., Kull I., Kvedariene V., Larenas-Linnemann D., Le L.T., Lemière C., Li J., Lieberman P., Lipworth B., Mahboub B., Makela M.J., Martin F., Marshall G.D., Martinez F.D., Masjedi M.R., Maurer M., Mavale-Manuel S., Mazon A., Melen E., Meltzer E.O., Mendez N.H., Merk H., Mihaltan F., Mohammad Y., Morais-Almeida M., Muraro A., Nafti S., Namazova-Baranova L., Nekam K., Neou A., Niggemann B., Nizankowska-Mogilnicka E., Nyembue T.D., Okamoto Y., Okubo K., Orru M.P., Ouedraogo S., Ozdemir C., Panzner P., Pali-Schöll I., Park H.S., Pigearias B., Pohl W., Popov T.A., Postma D.S., Potter P., Rabe K.F., Ratomaharo J., Reitamo S., Ring J., Roberts R., Rogala B., Romano A., Roman Rodriguez M., Rosado-Pinto J., Rosenwasser L., Rottem M., Sanchez-Borges M., Scadding G.K., Schmid-Grendelmeier P., Sheikh A., Sisul J.C., Solé D., Sooronbaev T., Spicak V., Spranger O., Stein R.T., Stoloff S.W., Sunyer J., Szczeklik A., Todo-Bom A., Toskala E., Tremblay Y., Valenta R., Valero A.L., Valeyre D., Valiulis A., Valovirta E., Van Cauwenberge P., Vandenplas O., van Weel C., Vichyanond P., Viegi G., Wang D.Y., Wickman M., Wöhrl S., Wright J., Yawn B.P., Yiallouros P.K., Zar H.J., Zernotti M.E., Zhong N., Zidarn M., Zuberbier T., Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs, 10.1016/j.jaci.2012.07.053
Bibliographic reference Cingi, Cemal ; Gevaert, Philippe ; Mösges, Ralf ; Rondon, Carmen ; Hox, Valérie ; et. al. Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report.. In: Clinical and Translational Allergy, Vol. 7, p. 17 [1-12] (2017)
Permanent URL http://hdl.handle.net/2078.1/191171