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Safety analysis of the oncological outcome after vein-preserving surgery for colorectal liver metastases detached from the main hepatic veins.

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Tomassini, Federico Bonadio, Italo Smeets, Peter De Paepe, Karen Berardi, Giammauro Libbrecht, Louis [UCL] Troisi, Roberto I

PURPOSE: Recent studies have reported that margins alone do not predict survival in patients with a positive chemotherapy response. The aim of this retrospective study is to analyze the surgical and oncological outcomes of patients who underwent chemotherapy and liver resection for colorectal liver metastases (CRLM) with lesions detached from the main hepatic veins, comparing the vein-preserving (VP) approach with traditional surgery. METHODS: Fourteen patients undergoing VP surgery from January 2006 to January 2013 were matched in a 1:2 ratio with a control group (CG) of 28 patients undergoing traditional resection. RESULTS: The median follow-up was 43 months. The radiological response was classified as 'partial response' in eight VP patients and 11 controls (57 vs. 39 %, p = 0.249) and as 'stable disease' in three VP patients and 9 controls (21 vs. 32 %, p = 0.465). Ten VP (71.4 %) and twenty CG patients (71.4 %) experienced tumor relapse (p = 0.99). No venous edge recurrences were recorded in the VP group, whereas 1/13 (7.7 %) was observed in the control group (p = 0.99). The pathological response rate was 64 vs. 39 % (p = 0.037) in VP and CG patients, respectively. The 5-year recurrence-free survival rate was 24 % for VP patients and 25 % for CG patients (p = 0.431). CONCLUSION: In patients with a positive CT response, CRLM can be detached from the hepatic veins, as the oncological outcome is similar to that of a larger resection. The VP approach offers the possibility to enlarge the surgical indications, thus optimizing future surgical treatment chances.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Langenbecks Archives of Surgery" - Vol. 400, no.6, p. 683-691 (2015)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 1435-2443
e-issn 1435-2451
Publication status Publié
Affiliation UCL - SSS/IREC - Institut de recherche expérimentale et clinique
MESH Subject Aged ; Neoplasm Recurrence, Local ; Retrospective Studies ; Treatment Outcome ; Colorectal Neoplasms ; Female ; Hepatectomy ; Hepatic Veins ; Humans ; Liver Neoplasms ; Male ; Middle Aged
Keywords Parenchyma-sparing liver resection ; Surgical treatment of colorectal liver metastases ; Laparoscopic liver surgery ; Chemotherapy and liver surgery ; Chemotherapy and colorectal liver metastases
Links
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Bibliographic reference Tomassini, Federico ; Bonadio, Italo ; Smeets, Peter ; De Paepe, Karen ; Berardi, Giammauro ; et. al. Safety analysis of the oncological outcome after vein-preserving surgery for colorectal liver metastases detached from the main hepatic veins.. In: Langenbecks Archives of Surgery, Vol. 400, no.6, p. 683-691 (2015)
Permanent URL http://hdl.handle.net/2078.1/186978