The effect of naftidrofuryl in patients with intermittent claudication, an assessment in general practice using the Clau-S Short Form,

Liard, F Boccalon, H Lehert, Philippe [FUCAM]

(eng) Clau-S questionnaire has recently be considered as one of the best Qol specific instruments for PAD. A 9-items short version was derived for use in General practice. a cohort of 780 patients was prospectively followed during 6 months where each patient received a treatment known to increase QoL (Naftidrofuryl 600mg daily). A secondary objective was to study the effect of physical exercise PE and smoking cessation SC on improvement in QoL, together with the use of a pharmacological agent. Results were: The sample was representative of PAD Stage II population, for general score as well as physical PH and mental MT subscores, internal consistency was constantly <.85, and estimated Standard Error or Measurement for MT was 6.59 (95% Upper CI=10.87). Thus the short scale preserves the same reliability as the whole Clau-S. Sensitivity to change was estimated by Effect sizes ES=.89, a value at least as large as earlier studies on both QoL and Walking distances.