Dedobbeleer, Olivier
[UCL]
Stockis, Julie
[UCL]
van der Woning, Bas
Coulie, Pierre G.
[UCL]
Lucas, Sophie
[UCL]
Production of active TGF-β is regulated at a posttranslational level and implies release of the mature cytokine dimer from the inactive, latent TGF-β precursor. There are several cell-type specific mechanisms of TGF-β activation. We identified a new mechanism operating on the surface of human regulatory T cells and involving membrane protein GARP, which binds latent TGF-β1. The paracrine activity of regulatory T cell-derived TGF-β1 contributes to immunosuppression and can be inhibited with anti-GARP Abs. Whether other immune cell types use surface GARP to activate latent TGF-β1 was not known. We show in this study that stimulated, human B lymphocytes produce active TGF-β1 from surface GARP/latent TGF-β1 complexes with isotype switching to IgA production.
Bibliographic reference |
Dedobbeleer, Olivier ; Stockis, Julie ; van der Woning, Bas ; Coulie, Pierre G. ; Lucas, Sophie. Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA.. In: Journal of Immunology, Vol. 199, no. 2, p. 391-396 (2017) |
Permanent URL |
http://hdl.handle.net/2078.1/186084 |