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Cancer vaccines

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Reilly, R Todd Machiels, Jean-Pascal [UCL] Jaffee, Elizabeth M

Abstract Immunotherapy is an alternative to more traditional forms of anticancer therapy that has the ability to activate tumour-specific humoral and cellular immune responses. As immunotherapeutic effects occur via mechanisms that are distinct from traditional therapies, such as surgery, radiotherapy and chemotherapy, cancer vaccines represent an additional treatment option with an entirely different spectrum of toxicities. This allows for the use of immunotherapy in conjunction with existing treatment options. This review describes several recent antitumour vaccines that employ whole tumour cells, antigen mimicry, antigen-pulsed dendritic cells and recombinant viruses to deliver antigen for the generation of an effective antitumour immune response. With an improved understanding of tumour immunology as well as the events that are required to generate an optimal immune response, the possibility of designing effective cancer vaccine approaches that induce both humoral and cellular responses has become even more realistic.

Document type Article de périodique (Journal article) – Synthèse de littérature
Publication date 2005
Language Anglais
Journal information "Emerging Drugs" - Vol. 5, no. 2, p. 201-209 (2005)
Peer reviewed yes
Publisher Ashley Publications ((United Kingdom) London)
issn 1361-9195
Publication status Publié
Affiliations UCL - (SLuc) Unité d'oncologie médicale
UCL - MD/MINT - Département de médecine interne
Keywords Allogeneic vaccine ; Antigen ; Antigen mimicry ; Anti-idiotype vaccine ; Autologous vaccine ; Cancer vaccine ; Dendritic cell ; Recombinant virus
Links
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Bibliographic reference Reilly, R Todd ; Machiels, Jean-Pascal ; Jaffee, Elizabeth M. Cancer vaccines. In: Emerging Drugs, Vol. 5, no. 2, p. 201-209 (2005)
Permanent URL http://hdl.handle.net/2078.1/185648