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Group A streptococcal meningitis: emm type distribution and theoretical vaccine coverage in children.

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Tuerlinckx, David [UCL] Gueulette, Emmanuelle Loens, Katherine Goossens, Herman Smeesters, Pierre Robert

As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2016
Language Anglais
Journal information "Acta clinica Belgica" - Vol. 71, no. 3, p. 138-141 (2016)
Peer reviewed yes
Publisher Taylor & Francis ((United Kingdom) Abingdon)
issn 1784-3286
e-issn 2295-3337
Publication status Publié
Affiliations UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - (MGD) Service de pédiatrie
MESH Subject Antigens, Bacterial ; Male ; Meningitis, Bacterial ; Retrospective Studies ; Streptococcal Infections ; Streptococcal Vaccines ; Streptococcus pyogenes ; Bacterial Outer Membrane Proteins ; Belgium ; Carrier Proteins ; Child ; Child, Preschool ; Female ; Humans ; Infant
Links
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Bibliographic reference Tuerlinckx, David ; Gueulette, Emmanuelle ; Loens, Katherine ; Goossens, Herman ; Smeesters, Pierre Robert. Group A streptococcal meningitis: emm type distribution and theoretical vaccine coverage in children.. In: Acta clinica Belgica, Vol. 71, no. 3, p. 138-141 (2016)
Permanent URL http://hdl.handle.net/2078.1/183653