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2p24.1p23.2 deletion and delayed recovery after a general anesthesia for gastrointestinal endoscopic procedure

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Dewe, Guillaume [UCL] Hermans, Emmanuel [UCL] Lavand'homme, Patricia [UCL]

Interstitial 2p deletions are very rare and may include proopiomelanocortin (POMC) gene (2p23.3). Our 10-year-old patient, known to carry this genetic anomaly, underwent an endoscopic interventional procedure under general anesthesia. After a sevoflurane induction, alfentanil (8.5 lgkg1) was given. The procedure lasted 22 min. There was an unexpected delayed recovery likely reflecting an unexpected delayed recovery likely due to opioid hypersensitivity. The deletion of POMC may cause a deficit in endorphin and may lead to an up-regulation of opioid receptors. Exogenous opioids should be used with particular caution in patients suffering a deficit of POMC.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "Paediatric Anaesthesia" - (2017)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. ((United Kingdom) Chichester)
issn 1155-5645
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'anesthésiologie
Keywords Congenital ; Delayed emergence from anesthesia ; Deletion 2p ; Opioid ; Pediatric obesity ; Pharmacodynamics
Links
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Bibliographic reference Dewe, Guillaume ; Hermans, Emmanuel ; Lavand'homme, Patricia. 2p24.1p23.2 deletion and delayed recovery after a general anesthesia for gastrointestinal endoscopic procedure. In: Paediatric Anaesthesia, (2017)
Permanent URL http://hdl.handle.net/2078.1/183006