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Targeting the Tumor Environment in Squamous Cell Carcinoma of the Head and Neck.

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Schmitz, Sandra [UCL] Machiels, Jean-Pascal [UCL]

The survival rate for patients with advanced stages of squamous cell carcinoma of the head and neck (SCCHN) remains poor despite multimodal treatment options. Cetuximab, an anti-EGFR inhibitor, is the only FDA-approved targeted agent for this disease. Recent findings have implicated modifications of the microenvironment and, consequently, phenotypical modifications of the cancer cell, in treatment resistance mechanisms. For many years, cancer research has focused mainly on targetable sites on or inside the cancer cell. Nowadays, in preclinical and clinical studies, a greater emphasis is being placed on drugs that target the tumor microenvironment. Potential targets relate to tumor vascularization, immunology, extracellular matrix components, or cancer-associated fibroblasts. The combination of these new agents with standard treatment options is of particular interest to overcome resistance mechanisms and/or to increase treatment efficacy. Whereas antiangiogenic agents show poor clinical activity, immunotherapy seems to be a more promising tool with an objective response rate (ORR) of 20 % in patients with recurrent and/or metastatic squamous cell carcinoma (R/M SCC). Other targets, located inside the extracellular matrix or on cancer associated fibroblasts, are under preclinical investigation. These new agents all need to be tested in clinical trials alone, or in combination with standard treatment modalities, based on preclinical data. To increase our knowledge of the complex network between the cancer cell and its environment, preclinical studies should consider co-culture models, and clinical studies should incorporate a translational research objective.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Current Treatment Options in Oncology" - Vol. 17, no.7, p. 37 [1-16] (2016)
Peer reviewed yes
Publisher Springer Healthcare ((United States) Philadelphia, PA)
issn 1527-2729
e-issn 1534-6277
Publication status Publié
Affiliations UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Unité d'oncologie médicale
UCL - (SLuc) Service d'oto-rhino-laryngologie
Keywords Angiogenesis ; Cancer associated fibroblasts ; Clinical data ; Extracellular matrix ; Head and neck cancer ; Immunology ; New treatment options ; Preclinical data ; Squamous cell carcinoma
Links
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Bibliographic reference Schmitz, Sandra ; Machiels, Jean-Pascal. Targeting the Tumor Environment in Squamous Cell Carcinoma of the Head and Neck.. In: Current Treatment Options in Oncology, Vol. 17, no.7, p. 37 [1-16] (2016)
Permanent URL http://hdl.handle.net/2078.1/182657