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NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy

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Van Acker, Nathalie Rage, Michaël [UCL] Vermeirsch, Hilde Schrijvers, Dorien Nuydens, Rony Plaghki, Léon [UCL] Yagihashi, Soroku

The in vivo cutaneous nerve regeneration model using capsaicin is applied extensively to study the regenerative mechanisms and therapeutic efficacy of disease modifying mole- cules for small fiber neuropathy (SFN). Since mismatches between functional and morpho- logical nerve fiber recovery are described for this model, we aimed at determining the capability of the capsaicin model to truly mimic the morphological manifestations of SFN in diabetes. As nerve and blood vessel growth and regenerative capacities are defective in diabetes, we focused on studying the key regulator of these processes, the neuropilin-1 (NRP-1)/semaphorin pathway. This led us to the evaluation of NRP-1 receptor expression in epidermis and dermis of subjects presenting experimentally induced small fiber neuropa- thy, diabetic polyneuropathy and of diabetic subjects without clinical signs of small fiber neuropathy. The NRP-1 receptor was co-stained with CD31 vessel-marker using immuno- fluorescence and analyzed with Definiens1 technology. This study indicates that capsaicin application results in significant loss of epidermal NRP-1 receptor expression, whereas dia- betic subjects presenting small fiber neuropathy show full epidermal NRP-1 expression in contrast to the basal expression pattern seen in healthy controls. Capsaicin induced a decrease in dermal non-vascular NRP-1 receptor expression which did not appear in dia- betic polyneuropathy. We can conclude that the capsaicin model does not mimic diabetic neuropathy related changes for cutaneous NRP-1 receptor expression. In addition, our data suggest that NRP-1 might play an important role in epidermal nerve fiber loss and/or defec- tive regeneration and that NRP-1 receptor could change the epidermal environment to a nerve fiber repellant bed possibly through Sem3A in diabetes.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2016
Language Anglais
Journal information "PLoS One" - Vol. 11, no. 9, p. e0161441 [1-19] (2016)
Peer reviewed yes
Publisher Public Library of Science ((United States) San Francisco, CA)
e-issn 1932-6203
Publication status Publié
Affiliations UCL - (SLuc) Service de médecine physique et de réadaptation motrice
UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
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Bibliographic reference Van Acker, Nathalie ; Rage, Michaël ; Vermeirsch, Hilde ; Schrijvers, Dorien ; Nuydens, Rony ; et. al. NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy. In: PLoS One, Vol. 11, no. 9, p. e0161441 [1-19] (2016)
Permanent URL http://hdl.handle.net/2078.1/182546