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Antiviral defenses in plants through genome editing

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Romay Gonzalez, Gustavo [UCL] Bragard, Claude [UCL]

Plant–virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease. GES are engineered to target and introduce mutations, which can be deleterious, via double-strand breaks at specific DNA sequences by the error-prone non-homologous recombination end-joining pathway. Although GES have been engineered to target DNA, recent discoveries of GES targeting ssRNA molecules, including virus genomes, pave the way for further studies programming plant defense against RNA viruses. Most of plant virus species have an RNA genome and at least 784 species have positive ssRNA. Here, we provide a summary of the latest progress in plant antiviral defenses mediated by GES. In addition, we also discuss briefly the GES perspectives in light of the rebooted debate on genetic modified organisms (GMOs) and the current regulatory frame for agricultural products involving the use of such engineering technologies. Introduction

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "Frontiers in Microbiology" - Vol. 8, no.47, p. 1-11 (2017)
Peer reviewed yes
Publisher Frontiers Media
issn 1664-302X
e-issn 1664-302X
Publication status Publié
Affiliation UCL - SST/ELI/ELIM - Applied Microbiology
Keywords 3130
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Bibliographic reference Romay Gonzalez, Gustavo ; Bragard, Claude. Antiviral defenses in plants through genome editing. In: Frontiers in Microbiology, Vol. 8, no.47, p. 1-11 (2017)
Permanent URL http://hdl.handle.net/2078.1/182360