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Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination.

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Blancquaert, Laura Baba, Shahid P Kwiatkowski, Sebastian Stautemas, Jan Stegen, Sanne Veiga da Cunha, Maria [UCL] Everaert, Inge

Using recombinant DNA technology, the present study provides the first strong and direct evidence indicating that β-alanine is an efficient substrate for the mammalian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transaminase. The concentration of carnosine and anserine in murine skeletal and heart muscle depends on circulating availability of β-alanine, which is in turn controlled by degradation of β-alanine in liver and kidney. Chronic oral β-alanine supplementation is a popular ergogenic strategy in sports because it can increase the intracellular carnosine concentration and subsequently improve the performance of high-intensity exercises. The present study can partly explain why the β-alanine supplementation protocol is so inefficient, by demonstrating that exogenous β-alanine can be effectively routed toward oxidation.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2016
Language Anglais
Journal information "The Journal of Physiology" - Vol. 594, no.17, p. 4849-4863 (2016)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 0022-3751
e-issn 1469-7793
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
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Bibliographic reference Blancquaert, Laura ; Baba, Shahid P ; Kwiatkowski, Sebastian ; Stautemas, Jan ; Stegen, Sanne ; et. al. Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination.. In: The Journal of Physiology, Vol. 594, no.17, p. 4849-4863 (2016)
Permanent URL http://hdl.handle.net/2078.1/181942