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Ruptured aortic aneurysm due to Mycobacterium bovis BCG with a delayed bacteriological diagnosis due to false negative result of the MPB 64 immunochromatographic assay.

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Simar, Joanna [UCL] Belkhir, Leïla [UCL] Tombal, Bertrand [UCL] André, Emmanuel [UCL]

Adjuvant therapy with bacillus Calmette-Guerin (BCG), a live attenuated strain of Mycobacterium bovis, has become the treatment of choice for low-risk superficial bladder carcinoma following transurethral resection of the bladder. Complications following vesical BCG instillations are uncommon but, in some cases, severe side-effects can occur such as sepsis or mycotic aneurysm. Besides usual laboratory techniques used for the diagnosis of Mycobacterium tuberculosis complex (MTBC) infections (smear microscopy and cultures), commercial immunochromatographic assays detecting MBP64, a 24 kDa M. tuberculosis complex-specific secretory protein, can rapidly distinguish MTBC and non-tuberculosis mycobacteria (NTM). MPB64 is found in M. tuberculosis, M. bovis and some but not all substrains of M.bovis BCG. Therefore, these immunochromatographic tests can lead to false negative results and delayed bacteriological diagnosis depending on the presence or absence of MPB64 protein in BCG substrains used for intravesical therapy.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "BMC Research Notes" - Vol. 10, no.1, p. 64 (2017)
Peer reviewed yes
Publisher BioMed Central Ltd. (London)
issn 1756-0500
e-issn 1756-0500
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale
UCL - (SLuc) Service de microbiologie
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
UCL - (SLuc) Service d'urologie
Keywords BCG therapy ; Case report ; MPB64 immunchromatographic assays ; Mycobacterium tuberculosis complex infections
Links
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Bibliographic reference Simar, Joanna ; Belkhir, Leïla ; Tombal, Bertrand ; André, Emmanuel. Ruptured aortic aneurysm due to Mycobacterium bovis BCG with a delayed bacteriological diagnosis due to false negative result of the MPB 64 immunochromatographic assay.. In: BMC Research Notes, Vol. 10, no.1, p. 64 (2017)
Permanent URL http://hdl.handle.net/2078.1/181913