Orofacial cleft (OFC) is the most prevalent craniofacial birth defect. Genes involved in one-carbon, folate and vitamin B12 metabolisms have been associated with OFC but no study performed a concomitant assessment on genes involved in these three pathways.
"Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics" - Vol. 53, no.12, p. 828-834 (2016)
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Goffinet, Laetitia ; Oussalah, Abderrahim ; Guéant-Rodriguez, Rosa-Maria ; Chery, Céline ; Basha, Mirta ; et. al. Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations.. In: Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics, Vol. 53, no.12, p. 828-834 (2016)
