User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

To chew or not to chew: that's the question.

Primary tabs

Yildiz, Halil [UCL] Komuta, Mina [UCL] Monsalve, Constanza Starkel, Peter [UCL] Lefebvre, Chantal [UCL]

A 25-year-old Somalian man was referred to the department of internal medicine because of nausea, vomiting and jaundice of recent onset. On physical examination, he was frankly icteric without clinical signs of chronic liver disease. Laboratory data showed evidence of acute hepatitis. Viral serologic tests for hepatitis A, B, C and E were negative. Antinuclear antibodies (ANA) were positive (titre 1 : 1280; speckled pattern, NV < 1 : 40) as well anti-actin antibodies (titre 75 UA, NV < 20). A liver biopsy was performed and showed a feature compatible with toxic hepatitis. On further questioning, the patient admitted to daily chew Khat when he was living in Somalia. We concluded to Khat-induced toxic hepatitis together with high-titre anti-nuclear antibody mimicking serologic patterns of auto-immune hepatitis.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2016
Language Anglais
Journal information "Acta clinica Belgica" - Vol. 71, no. 3, p. 187-189 (2016)
Peer reviewed yes
Publisher Taylor & Francis ((United Kingdom) Abingdon)
issn 1784-3286
e-issn 2295-3337
Publication status Publié
Affiliations UCL - SSS/IREC-Institut de recherche expérimentale et clinique
UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Service d'hépato-gastro-entérologie
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
Keywords Autoimmune hepatitis ; Catha edulis ; Hepatitis ; Herbal medicine ; Kath
Links
  1. CARLSSON C, Herbs and hepatitis, 10.1016/0140-6736(90)92538-s
  2. Teschke R, Br J Clin Pharmacol, 75, 630 (2012)
  3. Haller C. A, Making a diagnosis of herbal-related toxic hepatitis, 10.1136/ewjm.176.1.39
  4. Teschke Rolf, Eickhoff Axel, Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps, 10.3389/fphar.2015.00072
  5. Teschke R, Ann Hepatol, 14, 7 (2015)
  6. Harrison Phillip M., Wendon Julia A., Gimson Alexander E.S., Alexander Graeme J.M., Williams Roger, Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure, 10.1056/nejm199106273242604
  7. Al-Habori Molham, The potential adverse effects of habitual use ofCatha edulis(khat), 10.1517/14740338.4.6.1145
  8. Brostoff J.M., Plymen C., Birns J., Khat — a novel cause of drug-induced hepatitis, 10.1016/j.ejim.2005.12.010
  9. Chapman Michael H., Kajihara Mikio, Borges Gina, O'Beirne James, Patch David, Dhillon Amar P., Crozier Alan, Morgan Marsha Y., Severe, Acute Liver Injury and Khat Leaves, 10.1056/nejmc0908038
  10. Forbes Malcolm P, Raj Ashok S, Martin Jennifer, Lampe Guy, Powell Elizabeth E, Khat-associated hepatitis, 10.5694/mja13.10951
  11. Stuyt Rogier J. L., Willems Stefan M., Wagtmans Martin J., van Hoek Bart, Chewing khat and chronic liver disease : Letter to the Editor, 10.1111/j.1478-3231.2010.02440.x
  12. Roelandt P., George C., d'Heygere F., Aerts R., Monbaliu D., Laleman W., Cassiman D., Verslype C., van Steenbergen W., Pirenne J., Wilmer A., Nevens F., Acute Liver Failure Secondary to Khat (Catha edulis)–Induced Necrotic Hepatitis Requiring Liver Transplantation: Case Report, 10.1016/j.transproceed.2011.09.032
  13. Riyaz Shahzad, Khat (Catha Edulis) as a possible cause of autoimmune hepatitis, 10.4254/wjh.v6.i3.150
Bibliographic reference Yildiz, Halil ; Komuta, Mina ; Monsalve, Constanza ; Starkel, Peter ; Lefebvre, Chantal. To chew or not to chew: that's the question.. In: Acta clinica Belgica, Vol. 71, no. 3, p. 187-189 (2016)
Permanent URL http://hdl.handle.net/2078.1/180112