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Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics

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Neyrinck, Audrey M. [UCL] Pachikian, Barbara D. [UCL] Taminiau , Bernard Daube , Georges Frédérick, Raphaël [UCL] Cani, Patrice D. [UCL] Bindels, Laure B. [UCL] Delzenne, Nathalie M. [UCL]

Inulin-type fructans (ITF) are known for their capacity to modulate gut microbiota, energy metabolism and to improve glycemia in several animal models of obesity, and in humans. The potential contribution of ITF as modulators of sugar digestion by host enzymes has not been evaluated yet. A sucrose challenge has been performed on naive mice fed a standard diet supplemented with or without native chicory inulin (Fibruline 5%) for 3 weeks. The area under the curve of glycemia as well as sucrase activity in the small intestine were lowered after inulin treatment. Pyrosequencing of the 16S rRNA gene confirmed important changes in gut microbiota (mostly in favor of Blautia genus) due to inulin extract supplementation. Interestingly, the suppressive effect of inulin extract on postprandial glycemia also occurred when inulin was directly added to the sucrose solution, suggesting that the effect on sucrose digestion did not require chronic inulin administration. In vitro tests confirmed a direct inhibition of sucrase enzyme by the inulin extract, thereby suggesting that native chicory inulin, in addition to its well-known prebiotic effect, is also able to decrease the digestibility of carbohydrates, a phenomenon that can contribute in the control of post prandial glycemia. We may not exclude that the sucrose escaping the digestion could also contribute to the changes in the gut microbiota after a chronic treatment with inulin.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2016
Language Anglais
Journal information "PLoS One" - Vol. 11, no.8, p. e0160488 [1-13] (2016)
Peer reviewed yes
Publisher Public Library of Science ((United States) San Francisco, CA )
e-issn 1932-6203
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
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Bibliographic reference Neyrinck, Audrey M. ; Pachikian, Barbara D. ; Taminiau , Bernard ; Daube , Georges ; Frédérick, Raphaël ; et. al. Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics. In: PLoS One, Vol. 11, no.8, p. e0160488 [1-13] (2016)
Permanent URL http://hdl.handle.net/2078.1/179136