User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Towards human exploration of space: the THESEUS review series on neurophysiology research priorities

Primary tabs

download
  • Open access
  • PDF
  • 387.97 K
White, Olivier [Université de Bourgogne] Clément, Gilles Fortrat, Jacques-Olivier Pavy-LeTraon, Anne Thonnard, Jean-Louis [UCL] Paloski, William H

The THESEUS project (Towards Human Exploration of Space: a European Strategy), initiated within the seventh Framework Programme by the European Commission, aimed at providing a cross-cutting, life-science-based roadmap for Europe’s strategy towards human exploration of long space missions, and its relevance to applications on Earth. This topic was investigated by experts in the field, in the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration. In particular, decades of research have shown that altered gravity impairs neurological responses at large, such as perception, sleep, motor control, and cognitive factors. International experts established a list of key issues that should be addressed in that context and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2016
Language Anglais
Journal information "N P J Microgravity" - Vol. 2, p. 16023 [1-7] (2016)
Peer reviewed yes
Publisher Nature Publishing Group ((United States) New York, NY)
e-issn 2373-8065
Publication status Publié
Affiliations UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
UCL - (SLuc) Service de médecine physique et de réadaptation motrice
Louvain Bionics - Center of Interdisciplinary Expertise
Links
  1. Paloski, W. H. et al. Risk of sensory-motor performance failures affecting vehicle control during space missions: a review of the evidence. J. Gravit. Physiol. 15, 1–29 (2008).
  2. Gurfinkel V. S., Lestienne F., Levik Yu. S., Popov K. E., Lefort L., Egocentric references and human spatial orientation in microgravity : II. Body-centred coordinates in the task of drawing ellipses with prescribed orientation, 10.1007/bf00229792
  3. Merfeld, D. M., Young, L. R., Oman, C. M. & Shelhamer, M. J. A multidimensional model of the effect of gravity on the spatial orientation of the monkey. J. Vestib. Res. 3, 141–161 (1993).
  4. Oman C. M . In: Levels of Perception (eds Harris L & Jenkin Meditors) 375–398 (Springer, New York, NY, USA, 2003).
  5. Clément Gilles, Moore Steven, Raphan Theodore, Cohen Bernard, Perception of tilt (somatogravic illusion) in response to sustained linear acceleration during space flight, 10.1007/s002210100706
  6. Ross H, Brodie E, Benson A, Mass discrimination during prolonged weightlessness, 10.1126/science.6729479
  7. Zago Myrka, Lacquaniti Francesco, Visual perception and interception of falling objects: a review of evidence for an internal model of gravity, 10.1088/1741-2560/2/3/s04
  8. Black, F. O. et al. Disruption of postural readaptation by inertial stimuli following space flight. J. Vestibul. Res. Equil. 9, 369–378 (1999).
  9. Oman C.M., Lichtenberg B.K., Money K.E., McCoy R.K., M.I.T./Canadian vestibular experiments on the Spacelab-1 mission: 4. Space motion sickness: symptoms, stimuli, and predictability, 10.1007/bf00237749
  10. Reschke Millard F, Bloomberg Jacob J, Harm Deborah L, Paloski William H, Layne Charles, McDonald Vernon, Posture, locomotion, spatial orientation, and motion sickness as a function of space flight, 10.1016/s0165-0173(98)00031-9
  11. Kornilova, L. N. et al. Pathogenesis of sensory disorders in microgravity. Physiologist 34, S36–S39 (1991).
  12. Lipshits, M. I., Gurfinkel, E. V., Matsakis, Y. & Lestienne, F. The effect of weightlessness on sensorimotor interaction during operator activity: visual feedback. Motor response latency time. Aerospace Environ. Med. 27, 22–25 (1993).
  13. Angelaki, D. E., McHenry, M. Q., Dickman, J. D., Newlands, S. D. & Hess, B. J. M. Computation of inertial motion: neural strategies to resolve ambiguous otolith information. J. Neurosci. 19, 316–327 (1999).
  14. Manzey Dietrich, Lorenz Bernd, Schiewe Albrecht, Finell Georg, Thiele Gerhard, Dual-Task Performance in Space: Results from a Single-Case Study during a Short-Term Space Mission, 10.1518/001872095778995599
  15. Shelhamer Mark, Trends in sensorimotor research and countermeasures for exploration-class space flights, 10.3389/fnsys.2015.00115
  16. Kanas N. & Manzey D. In: Space Psychology and Psychiatry (eds) 49–88 (Springer, 2010).
  17. Mader, T. H., Taylor, G. R., Hunter, N., Caputo, M. & Meehan, R. T. Intraocular-pressure, retinal vascular, and visual-acuity changes during 48 hours of 10-degrees head-down tilt. Aviat. Space Environ. Med. 61, 810–813 (1990).
  18. Linenger, J. M. Off The Planet: Surviving Five Perilous Months Aboard the Space Station Mir (McGraw-Hill CIE, 2000).
  19. Richards, J. T., Clark, J. B., Oman, C. M. & Marshburn, T. H. Neurovestibular effects of long-duration spaceflight: a summary of MIR-Phase 1 experiences. J. Vestib. Res. 11, 322 (2002).
  20. Lackner James R, DiZio Paul, Motor function in microgravity: movement in weightlessness, 10.1016/s0959-4388(96)80023-7
  21. Sangals J�rg, Heuer Herbert, Manzey Dietrich, Lorenz Bernd, Changed visuomotor transformations during and after prolonged microgravity, 10.1007/s002210050906
  22. Watt, D. G. D. Pointing at memorized targets during prolonged microgravity. Aviat. Space Environ. Med. 68, 99–103 (1997).
  23. Shelhamer, M. & Zee, D. S. Context-specific adaptation and its significance for neurovestibular problems of space flight. J. Vestibul. Res. 13, 345–362 (2003).
  24. Shadmehr, R. Moussavi ZMK. Spatial generalization from learning dynamics of reaching movements. J. Neurosci. 20, 7807–7815 (2000).
  25. Bles W. et al. Space Adaptation Syndrome Induced by a Long Duration +3Gx Centrifuge Run. Report No., TNO-IZF1989-25, (TNO Institute for Sensory Physiology, Soesterberg, The Netherlands, 1989).
  26. Demertzi Athena, Van Ombergen Angelique, Tomilovskaya Elena, Jeurissen Ben, Pechenkova Ekaterina, Di Perri Carol, Litvinova Liudmila, Amico Enrico, Rumshiskaya Alena, Rukavishnikov Ilya, Sijbers Jan, Sinitsyn Valentin, Kozlovskaya Inessa B., Sunaert Stefan, Parizel Paul M., Van de Heyning Paul H., Laureys Steven, Wuyts Floris L., Cortical reorganization in an astronaut’s brain after long-duration spaceflight, 10.1007/s00429-015-1054-3
  27. Andre-Deshays, C. et al. Gaze control in microgravity. 1. Saccades, pursuit, eye-head coordination. J. Vestib. Res. 3, 331–343 (1993).
  28. Berger, M. et al. Pointing arm movements in short- and long-term spaceflights. Aviat. Space Environ. Med. 68, 781–787 (1997).
  29. Bock, O., Howard, I. P., Money, K. E. & Arnold, K. E. Accuracy of aimed arm movements in changed gravity. Aviat Space Environ. Med. 63, 994–998 (1992).
  30. Crevecoeur F., Thonnard J.-L., Lefevre P., Optimal Integration of Gravity in Trajectory Planning of Vertical Pointing Movements, 10.1152/jn.00113.2009
  31. Papaxanthis C., Pozzo T., Popov K. E., McIntyre J., Hand trajectories of vertical arm movements in one- G and zero- G environments, 10.1007/s002210050423
  32. White Olivier, Lefèvre Philippe, Wing Alan M., Bracewell R. Martyn, Thonnard Jean-Louis, Active Collisions in Altered Gravity Reveal Eye-Hand Coordination Strategies, 10.1371/journal.pone.0044291
  33. Augurelle Anne-Sophie, Penta Massimo, White Olivier, Thonnard Jean-Louis, The effects of a change in gravity on the dynamics of prehension, 10.1007/s00221-002-1322-3
  34. Bock, O. Grasping of virtual objects in changed gravity. Aviat. Space Environ. Med. 67, 1185–1189 (1996).
  35. Hermsdörfer J., Marquardt C., Philipp J., Zierdt A., Nowak D., Glasauer S., Mai N., Grip forces exerted against stationary held objects during gravity changes, 10.1007/s002210050730
  36. White Olivier, The brain adjusts grip forces differently according to gravity and inertia: a parabolic flight experiment, 10.3389/fnint.2015.00007
  37. White Olivier, McIntyre Joseph, Augurelle Anne-Sophie, Thonnard Jean-Louis, Do novel gravitational environments alter the grip-force/load-force coupling at the fingertips?, 10.1007/s00221-004-2175-8
  38. Anderson D.J., Reschke M.F., Homick J.E., Werness S.A.S., Dynamic posture analysis of Spacelab-1 crew members, 10.1007/bf00237754
  39. Jain Varsha, Wood Scott J., Feiveson Alan H., Black F. Owen, Paloski William H., Diagnostic Accuracy of Dynamic Posturography Testing After Short-Duration Spaceflight, 10.3357/asem.2710.2010
  40. Kenyon R.V., Young L.R., M.I.T./Canadian vestibular experiments on the Spacelab-1 mission: 5. Postural responses following exposure to weightlessness, 10.1007/bf00237750
  41. Bloomberg J.J., Mulavara A.P., Changes in walking strategies after spaceflight, 10.1109/memb.2003.1195697
  42. Clark Torin K., Newman Michael C., Merfeld Daniel M., Oman Charles M., Young Laurence R., Human manual control performance in hyper-gravity, 10.1007/s00221-015-4215-y
  43. Dahlman Joakim, Sjörs Anna, Lindström Johan, Ledin Torbjörn, Falkmer Torbjörn, Performance and Autonomic Responses During Motion Sickness, 10.1177/0018720809332848
  44. Paule Merle G., Chelonis John J., Blake Donna J., Dornhoffer John L., Effects of drug countermeasures for space motion sickness on working memory in humans, 10.1016/j.ntt.2004.07.002
  45. Sawin, C. S., Taylor, G. R. & Smith, W. L. Extended Duration Orbiter Medical Project Final Report: Section 5 Neurovestibular Dysfunction. Report Number NASA/SP–1999-534. (NASA, Lyndon B. Johnson Space Center Houston, TX, 1999).
  46. Barger Laura K, Flynn-Evans Erin E, Kubey Alan, Walsh Lorcan, Ronda Joseph M, Wang Wei, Wright Kenneth P, Czeisler Charles A, Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study, 10.1016/s1474-4422(14)70122-x
  47. Alhola, P. & Polo-Kantola, P. Sleep deprivation: impact on cognitive performance. Neuropsychiatr Dis. Treat. 3, 553–567 (2007).
  48. Bryant Penelope A., Trinder John, Curtis Nigel, Sick and tired: does sleep have a vital role in the immune system?, 10.1038/nri1369
  49. Williamson A M, Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication, 10.1136/oem.57.10.649
  50. Benson, A. J., Kass, J. R. & Vogel, H. European vestibular experiments on the Spacelab-1 Mission.4. thresholds of perception of whole-body linear oscillation. Exp. Brain Res. 64, 264–271 (1986).
  51. Benson, A. J. & Vieville, T. European vestibular experiments on the spacelab-1 mission.6. yaw axis vestibuloocular reflex. Exp. Brain Res. 64, 279–283 (1986).
  52. Clarke A.H., Grigull J., Mueller R., Scherer H., The three-dimensional vestibulo-ocular reflex during prolonged microgravity, 10.1007/s002210000476
  53. McIntyre J., Zago M., Berthoz A., Lacquaniti F., 10.1038/89477
  54. Young L., Oman C., Watt D., Money K., Lichtenberg B., Spatial orientation in weightlessness and readaptation to earth's gravity, 10.1126/science.6610215
  55. Ehrsson H. H., Imagery of Voluntary Movement of Fingers, Toes, and Tongue Activates Corresponding Body-Part-Specific Motor Representations, 10.1152/jn.01113.2002
  56. Sirigu A., Duhamel J.-R., Cohen L., Pillon B., Dubois B., Agid Y., The Mental Representation of Hand Movements After Parietal Cortex Damage, 10.1126/science.273.5281.1564
  57. Papaxanthis Charalambos, Paizis Christos, White Olivier, Pozzo Thierry, Stucchi Natale, The Relation between Geometry and Time in Mental Actions, 10.1371/journal.pone.0051191
  58. Blaber A. P., Goswami N., Bondar R. L., Kassam M. S., Impairment of Cerebral Blood Flow Regulation in Astronauts With Orthostatic Intolerance After Flight, 10.1161/strokeaha.110.610576
  59. Angelaki Dora E., Shaikh Aasef G., Green Andrea M., Dickman J. David, Neurons compute internal models of the physical laws of motion, 10.1038/nature02754
  60. Boyle, R. et al. Neural readaptation to earth's gravity following return from space. J. Neurophysiol. 86, 2118–2122 (2001).
  61. Indovina I., Representation of Visual Gravitational Motion in the Human Vestibular Cortex, 10.1126/science.1107961
  62. McNaughton Bruce L., Knierim James J., Poe Gina R., 10.1038/72910
  63. Ross Muriel D., Changes in Ribbon Synapses and Rough Endoplasmic Reticulum of Rat Utricular Macular Hair Cells in Weightlessness, 10.1080/000164800750045983
  64. Rousseau C., Fautrelle L., Papaxanthis C., Fadiga L., Pozzo T., White O., Direction-dependent activation of the insular cortex during vertical and horizontal hand movements, 10.1016/j.neuroscience.2016.03.039
  65. Johnsson A., Eidesmo T., Rhythmic biological systems under μg conditions, 10.1016/0273-1177(89)90083-5
  66. White O., Bleyenheuft Y., Ronsse R., Smith A. M., Thonnard J.-L., Lefevre P., Altered Gravity Highlights Central Pattern Generator Mechanisms, 10.1152/jn.90436.2008
  67. Hallgren Emma, Migeotte Pierre-François, Kornilova Ludmila, Delière Quentin, Fransen Erik, Glukhikh Dmitrii, Moore Steven T., Clément Gilles, Diedrich André, MacDougall Hamish, Wuyts Floris L., Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space, 10.1038/srep17627
  68. Vernikos Joan, Schneider Victor S., Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review, 10.1159/000252852
Bibliographic reference White, Olivier ; Clément, Gilles ; Fortrat, Jacques-Olivier ; Pavy-LeTraon, Anne ; Thonnard, Jean-Louis ; et. al. Towards human exploration of space: the THESEUS review series on neurophysiology research priorities. In: N P J Microgravity, Vol. 2, p. 16023 [1-7] (2016)
Permanent URL http://hdl.handle.net/2078.1/176592