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Non-invasive diagnosis of pulmonary hypertension from lung Doppler signal: a proof of concept study.

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Godinas, Laurent [UCL] Lador, Frédéric Schatzberger, Rachel Günther, Sven Segel, Michael J Simonneau, Gérald

Transthoracic Parametric Doppler (TPD) is a novel ultrasound technique recently developed for the investigation of pulmonary blood vessels. Lung Doppler Signals (LDS) recorded from TPD provide information regarding the functional mechanical characteristics of pulmonary blood vessels. We aimed to define the specific profile of LDS generated from TPD imaging in patients with pulmonary hypertension (PH), and to evaluate the diagnostic performance of LDS to detect PH using right heart catheterization (RHC) as gold standard reference. Seventy nine PH patients and 79 healthy controls matched for age, gender and BMI were recruited in a prospective case-control multicenter study. LDS recordings were performed by TPD consisting of a pulsed Doppler with a 2 MHz single element transducer. LDS were recorded within 24 h of RHC. Following LDS extraction, classification and performance evaluation were performed offline using a support vector machine (k-fold cross validation method). The best LDS parameters for PH detection were (1) peak velocity of the systolic (S) and diastolic (D) signals, (2) the rise slope of the S and D signals, and (3) time to peak of the S signal. Overall, the sensitivity and specificity of TPD for detection of PH were 82.7 % (95 % CI 81.3-84.1) and 87.4 % (95 % CI 86.3-88.5), respectively, with an area under the receiver operating curve of 0.95 (95 % CI 0.94-0.96). Detection rate of PH increased progressively with the level of mean pulmonary artery pressure. LDS recorded by TPD display a specific profile in PH and appears to be a promising and reliable tool for PH diagnosis. Further studies are required to confirm the clinical usefulness of LDS.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "Journal of Clinical Monitoring and Computing" - Vol. 31, no. 5, p. 903-910 (2017)
Peer reviewed yes
Publisher Springer Netherlands ((Netherlands) Amsterdam)
issn 1387-1307
e-issn 1573-2614
Publication status Publié
Affiliations UCL - (MGD) Service de pneumologie
UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
Keywords Detection ; Lung doppler signal ; Non-invasive diagnosis ; Pulmonary hypertension ; Screening
Links
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Bibliographic reference Godinas, Laurent ; Lador, Frédéric ; Schatzberger, Rachel ; Günther, Sven ; Segel, Michael J ; et. al. Non-invasive diagnosis of pulmonary hypertension from lung Doppler signal: a proof of concept study.. In: Journal of Clinical Monitoring and Computing, Vol. 31, no. 5, p. 903-910 (2017)
Permanent URL http://hdl.handle.net/2078.1/176342