Correlation of endoscopic and pathological features of gastro-intestinal lymphomas

Camboni, Alessandra [UCL] Mavrogenis, Georgios [UCL] Piessevaux, Hubert [UCL] Denis, Marie Armelle [UCL] Dewit, Olivier [UCL] Jouret-Mourin, Anne [UCL]

The gastrointestinal (GI) tract is the most common extranodal site of lymphoma involvement. Primary lymphomas of the GI tract are rare, while secondary GI involvement is relatively common. Despite their rarity, primary lymphomas of the GI tract are important since their evaluation, diagnosis, management and prognosis are distinct from that of lymphoma at other sites and other cancers of the GI tract. In the last years many improvements have been done in the management of GI lymphomas. The new and more accurate endoscopic techniques enabled to better describe the endoscopic features of GI lymphomas with important contributions in the diagnosis, therapy and follow-up. Moreover, a better insight into GI lymphomas etiology and molecular signaling pathways also allowed an improvement in their management, in particular for the diagnosis and for the treatment strategies. We describe the endoscopic presentation of GI lymphomas according to the involved site and lymphoma subtypes. We also discuss the histo-pathological and molecular aspects of all subtypes of GI lymphomas.