User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes.

Primary tabs

Albert, Nathalie L Unterrainer, Marcus Diemling, Markus Xiong, Guoming Bartenstein, Peter Vander Borght, Thierry [UCL] la Fougère, Christian

(eng) PURPOSE: Even though [(123)I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS with previously inconclusive findings can be improved by the use of iterative reconstruction algorithms and an improved semiquantitative evaluation which additionally implemented a correction algorithm for patient age and gamma camera dependency (EARL-BRASS; Hermes Medical Solutions, Sweden). METHODS: We identified 101 patients with inconclusive findings who underwent an [(123)I]FP-CIT SPECT between 2003 and 2010 as part of the diagnostic process of suspected PS at the University of Munich, and re-evaluated these scans using iterative reconstruction algorithms and the new corrected EARL-BRASS. Clinical follow-up was obtained in 62 out of the 101 patients and constituted the gold standard for the re-evaluation to assess the possible improvement in diagnostic accuracy. RESULTS: Clinical follow-up confirmed the diagnosis of PS in 11 of the 62 patients. In patients in whom both visual and semiquantitative analysis showed concordant findings (48 patients), a high negative predictive value (93 %), positive predictive value (100 %) and accuracy (94 %) were found, and thus a correct diagnosis was obtained in 45 of the 48 patients. Among the 14 patients with discordant findings, the additional semiquantitative analysis correctly identified all five of nine patients patients without PS by nonpathological semiquantitative findings in visually pathological or inconclusive scans. In contrast, four of the remaining five patients with decreased semiquantitative values but visually normal scans did not show a PS during follow-up. CONCLUSION: The age-corrected and camera-corrected mode of evaluation using EARL-BRASS provided a notable improvement in the diagnostic accuracy of [(123)I]FP-CIT SPECT in PS patients with previously inconclusive findings. The gain in accuracy might be achieved by better discrimination between physiological low striatal [(123)I]FP-CIT binding due to age-related loss of the dopamine transporter or pathological loss of binding.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "European Journal of Nuclear Medicine and Molecular Imaging" - Vol. 43, no. 7, p. 1315-1322 (2016)
Peer reviewed yes
Publisher Springer ((Germany) Berlin)
issn 1619-7070
e-issn 1619-7089
Publication status Publié
Affiliations UCL - (MGD) Service de médecine nucléaire
UCL - SSS/IREC/MONT - Pôle Mont Godinne
Keywords Diagnostic accuracy ; EARL-BRASS ; Parkinsonian syndromes ; [123I]FP-CIT SPECT
Links
  1. Suwijn Sven R, van Boheemen Caroline JM, de Haan Rob J, Tissingh Gerrit, Booij Jan, de Bie Rob MA, The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review, 10.1186/s13550-015-0087-1
  2. Benamer Hani T. S., Patterson Jim, Grosset Donald G., Booij J., de Bruin K., van Royen E., Speelman J. D., Horstink M. H. I. M., Sips H. J. W. A., Dierckx R. A., Versijpt J., Decoo D., Van Der Linden C., Hadley D. M., Doder M., Lees A. J., Costa D. C., Gacinovic S., Oertel W. H., Pogarell O., Hoeffken H., Joseph K., Tatsch K., Schwarz J., Ries V., Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: The [123I]-FP-CIT study group, 10.1002/1531-8257(200005)15:3<503::aid-mds1013>3.0.co;2-v
  3. Darcourt Jacques, Booij Jan, Tatsch Klaus, Varrone Andrea, Vander Borght Thierry, Kapucu Özlem L., Någren Kjell, Nobili Flavio, Walker Zuzana, Van Laere Koen, EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2, 10.1007/s00259-009-1267-x
  4. McKeith Ian, O'Brien John, Walker Zuzana, Tatsch Klaus, Booij Jan, Darcourt Jacques, Padovani Alessandro, Giubbini Raffaele, Bonuccelli Ubaldo, Volterrani Duccio, Holmes Clive, Kemp Paul, Tabet Naji, Meyer Ines, Reininger Cornelia, Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study, 10.1016/s1474-4422(07)70057-1
  5. Booij Jan, Speelman Johannes D., Horstink Martin W. I. M., Wolters Erik C., The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism, 10.1007/s002590000460
  6. Scherfler Christoph, Schwarz Johannes, Antonini Angelo, Grosset Donald, Valldeoriola Francesc, Marek Kenneth, Oertel Wolfgang, Tolosa Eduardo, Lees Andrew J., Poewe Werner, Role of DAT-SPECT in the diagnostic work up of Parkinsonism, 10.1002/mds.21505
  7. Hughes Andrew J., Daniel Susan E., Ben‐Shlomo Yoav, Lees Andrew J., The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service, 10.1093/brain/awf080
  8. Plotkin M., Amthauer H., Klaffke S., K�hn A., L�demann L., Arnold G., Wernecke K.-D., Kupsch A., Felix R., Venz S., Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients, 10.1007/s00702-004-0208-x
  9. Catafau Ana M., Tolosa Eduardo, , Impact of dopamine transporter SPECT using123I-Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes, 10.1002/mds.20112
  10. Tolosa Eduardo, Borght Thierry Vander, Moreno Emilio, Accuracy of DaTSCAN (123I-ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-Year follow-up of an open-label study, 10.1002/mds.21710
  11. Varrone Andrea, Dickson John C., Tossici-Bolt Livia, Sera Terez, Asenbaum Susanne, Booij Jan, Kapucu Ozlem L., Kluge Andreas, Knudsen Gitte M., Koulibaly Pierre Malick, Nobili Flavio, Pagani Marco, Sabri Osama, Vander Borght Thierry, Van Laere Koen, Tatsch Klaus, European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis, 10.1007/s00259-012-2276-8
  12. Koch W, Pogarell O, Pöpperl G, Hornung J, Hamann C, Gildehaus F-J, et al. Extended studies of the striatal uptake of 99mTc-NC100697 in healthy volunteers. J Nucl Med. 2007;48:27–34.
  13. Tossici-Bolt Livia, Dickson John C., Sera Terez, de Nijs Robin, Bagnara Maria Claudia, Jonsson Catherine, Scheepers Egon, Zito Felicia, Seese Anita, Koulibaly Pierre Malick, Kapucu Ozlem L., Koole Michel, Raith Maria, George Jean, Lonsdale Markus Nowak, Münzing Wolfgang, Tatsch Klaus, Varrone Andrea, Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database, 10.1007/s00259-011-1801-5
  14. BECK A. T., An Inventory for Measuring Depression, 10.1001/archpsyc.1961.01710120031004
  15. Derogatis L. R., Rickels K., Rock A. F., The SCL-90 and the MMPI: a step in the validation of a new self-report scale, 10.1192/bjp.128.3.280
  16. Kangasmaa Tuija, Sohlberg Antti, Kuikka Jyrki T., Reduction of Collimator Correction Artefacts with Bayesian Reconstruction in Spect, 10.1155/2011/630813
  17. Koch Walter, Unterrainer Marcus, Xiong Guoming, Bartenstein Peter, Diemling Markus, Varrone Andrea, Dickson John C., Tossici-Bolt Livia, Sera Terez, Asenbaum Susanne, Booij Jan, Kapucu Ozlem L., Kluge Andreas, Ziebell Morten, Darcourt Jacques, Nobili Flavio, Pagani Marco, Hesse Swen, Vander Borght Thierry, Van Laere Koen, Tatsch Klaus, la Fougère Christian, Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls, 10.1007/s00259-014-2785-8
  18. Collins D. Louis, Neelin Peter, Peters Terrence M., Evans Alan C., Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space : , 10.1097/00004728-199403000-00005
  19. Koch W, Radau PE, Hamann C, Tatsch K. Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J Nucl Med. 2005;46:1109–18.
  20. Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., Mazoyer B., Joliot M., Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain, 10.1006/nimg.2001.0978
  21. Mozley PD, Acton PD, Barraclough ED, Plössl K, Gur RC, Alavi A, et al. Effects of age on dopamine transporters in healthy humans. J Nucl Med. 1999;40:1812–7.
  22. Schwarz J, Storch A, Koch W, Pogarell O, Radau PE, Tatsch K. Loss of dopamine transporter binding in Parkinson’s disease follows a single exponential rather than linear decline. J Nucl Med. 2004;45:1694–7.
  23. la Fougere C., Popperl G., Levin J., Wangler B., Boning G., Uebleis C., Cumming P., Bartenstein P., Botzel K., Tatsch K., The Value of the Dopamine D2/3 Receptor Ligand 18F-Desmethoxyfallypride for the Differentiation of Idiopathic and Nonidiopathic Parkinsonian Syndromes, 10.2967/jnumed.109.071811
  24. CHOUKER M., TATSCH K., LINKE R., POGARELL O., HAHN K., SCHWARZ J., Striatal dopamine transporter binding in early to moderately advanced Parkinsonʼs disease: monitoring of disease progression over 2 years : , 10.1097/00006231-200106000-00017
  25. Marek K, Seibyl J. Beta-CIT scans without evidence of dopaminergic deficit (SWEDD) in the ELLDOPA-CIT and CALM-cit study: long-term imaging assessment. Neurology. 2003;60:A293.
  26. Schwingenschuh Petra, Ruge Diane, Edwards Mark J., Terranova Carmen, Katschnig Petra, Carrillo Fatima, Silveira-Moriyama Laura, Schneider Susanne A, Kägi Georg, Palomar Francisco J, Talelli Penelope, Dickson John, Lees Andrew J., Quinn Niall, Mir Pablo, Rothwell John C., Bhatia Kailash P., Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: A clinical and electrophysiological study, 10.1002/mds.23019
Bibliographic reference Albert, Nathalie L ; Unterrainer, Marcus ; Diemling, Markus ; Xiong, Guoming ; Bartenstein, Peter ; et. al. Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes.. In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, no. 7, p. 1315-1322 (2016)
Permanent URL http://hdl.handle.net/2078.1/174853