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Olfaction in Chronic Rhinosinusitis

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Rombaux, Philippe [UCL] Huart, Caroline [UCL] Levie, P Cinqi, C Hummel, T

Olfactory dysfunction is a frequent complaint in chronic rhinosinusitis patients and has a significant impact on quality of life. Therefore, it is essential that clinicians are aware of the importance of olfactory dysfunction in chronic rhinosinusitis (CRS) patients and know how to deal with it. Notably, the evaluation of olfactory function (i.e., using psychophysical testing) and imagery of olfactory bulb play an important role in the evaluation of patients and give essential information about the "baseline" olfactory function. Because the high impact of olfactory function on quality of life and medical and/or surgical treatment should be proposed to patients. However, it remains difficult to predict the outcome of treatment as well as long-term efficacy. The first section of this review is dedicated to the assessment of olfactory function. Secondly, we will discuss the etiopathology of olfactory dysfunction in CRS with and without nasal polyps. Finally, we will review literature findings about the efficacy of different treatments on olfactory function.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Rhinosinusitis - Current Allergy and Asthma Reports" - Vol. 16, no.5, p. 41 (May 2016)
Peer reviewed yes
Publisher Springer (New York, NY)
issn 1529-7322
e-issn 1534-6315
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service d'oto-rhino-laryngologie
Keywords Chronic rhinosinusitis Smell Olfaction Nasal polyps
Links
  1. Landis B N., Konnerth C G., Hummel T, A Study on the Frequency of Olfactory Dysfunction : A Study on the Frequency of Olfactory Dysfunction, 10.1097/00005537-200410000-00017
  2. Mullol Joaquim, Alobid Isam, Mariño-Sánchez Franklin, Quintó Llorenç, de Haro Josep, Bernal-Sprekelsen Manuel, Valero Antonio, Picado Cèsar, Marin Concepció, Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study), 10.1136/bmjopen-2012-001256
  3. Fonteyn S., Huart C., Deggouj N., Collet S., Eloy P., Rombaux P., Non-sinonasal-related olfactory dysfunction: A cohort of 496 patients, 10.1016/j.anorl.2013.03.006
  4. Frasnelli Johannes, Hummel Thomas, Olfactory dysfunction and daily life, 10.1007/s00405-004-0796-y
  5. Neuland Claudia, Bitter Thomas, Marschner Heike, Gudziol Hilmar, Guntinas-Lichius Orlando, Health-related and specific olfaction-related quality of life in patients with chronic functional anosmia or severe hyposmia, 10.1002/lary.21387
  6. Deems D. A., Doty R. L., Settle R. G., Moore-Gillon V., Shaman P., Mester A. F., Kimmelman C. P., Brightman V. J., Snow J. B., Smell and Taste Disorders, A Study of 750 Patients From the University of Pennsylvania Smell and Taste Center, 10.1001/archotol.1991.01870170065015
  7. Doty Richard L., Shaman Paul, Kimmelman Charles P., Dann Michael S., University of pennsylvania smell identification test: A rapid quantitative olfactory function test for the clinic, 10.1288/00005537-198402000-00004
  8. Doty Richard L., Shaman Paul, Dann Michael, Development of the university of pennsylvania smell identification test: A standardized microencapsulated test of olfactory function, 10.1016/0031-9384(84)90269-5
  9. Doty Richard L., Marcus Avron, William Lee W., Development of the 12-Item Cross-Cultural Smell Identification Test(CC-SIT), 10.1097/00005537-199603000-00021
  10. Hummel T., Sekinger B., Wolf S.R., Pauli E., Kobal G., ‘Sniffin’ Sticks': Olfactory Performance Assessed by the Combined Testing of Odour Identification, Odor Discrimination and Olfactory Threshold, 10.1093/chemse/22.1.39
  11. Hummel Thomas, Rosenheim Kati, Konnerth Claus-Günther, Kobal Gerd, Screening of Olfactory Function with a Four-Minute Odor Identification Test: Reliability, Normative Data, and Investigations in Patients with Olfactory Loss, 10.1177/000348940111001015
  12. Thomas-Danguin T, Rouby C, Sicard G, et al. Development of the ETOC: a European test of olfactory capabilities. Rhinology. 2003;41(3):142–51.
  13. Cain WS, Gent JFn Goodspeed RB, Leonard G. Evaluation of the olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope. 1988;98(1):83–8.
  14. Cardesin A, Alobid I, Benitez P, Sierra E, de Haro J, Bernal-Sprekelsen M, et al. Barcelona Smell Test-24 (BAST-24): validation and smell characteristics in the healthy Spanish population. Rhinology. 2006;44(1):83–9.
  15. Briner HR, Simmen D. Smell diskettes as screening test of olfaction. Rhinology. 1999;37:145–8.
  16. Kondo Hiroko, Matsuda Toshi, Hashiba Motoyuki, Baba Shunkichi, A Study of the Relationship Between the T&T Olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese Population, 10.2500/105065898780182390
  17. Heilmann Stefan, Strehle Gundel, Rosenheim Kati, Damm Michael, Hummel Thomas, Clinical Assessment of Retronasal Olfactory Function, 10.1001/archotol.128.4.414
  18. Lapid H., Hummel T., Recording Odor-Evoked Response Potentials at the Human Olfactory Epithelium, 10.1093/chemse/bjs073
  19. Hummel T, Kobal G. Olfactory event-related potentials. In: Simon SA, Nicolelis MAL, editors. Methods and frontiers in chemosensory research. Boca Raton: CRC press; 2001. p. 429–64.
  20. Kobal G, Plattig KH. Methodische Anmerkungen zur Gewinnung olfaktorischer EEG-Antworten des wachen Menschen (objektive Olfaktometrie). Z EEG-EMG. 1978;9:135–45.
  21. Kobal G. Elektrophysiologische Untersuchungen des menschlichen Geruchssinns. Stuttgart: Thieme Verlag; 1981.
  22. Huart Caroline, Rombaux Philippe, Hummel Thomas, Plasticity of the Human Olfactory System: The Olfactory Bulb, 10.3390/molecules180911586
  23. Gudziol V., Buschhüter D., Abolmaali N., Gerber J., Rombaux P., Hummel T., Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study, 10.1093/brain/awp243
  24. Holbrook Eric H., Leopold Donald A., An updated review of clinical olfaction : , 10.1097/01.moo.0000193174.77321.39
  25. Mott April E., Leopold Donald A., Disorders in Taste and Smell, 10.1016/s0025-7125(16)30391-1
  26. Raviv Joseph R., Kern Robert C., Chronic sinusitis and olfactory dysfunction, 10.1016/j.otc.2004.06.003
  27. Seiden Allen M., Duncan Heather J., The Diagnosis of a Conductive Olfactory Loss, 10.1097/00005537-200101000-00002
  28. Bhattacharyya N. The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol. 2003;17(1):27–32.
  29. Litvack Jamie R., Fong Karen, Mace Jess, James Kenneth E., Smith Timothy L., Predictors of Olfactory Dysfunction in Patients With Chronic Rhinosinusitis : , 10.1097/mlg.0b013e318184e216
  30. Orlandi RR, Terrell JE. Analysis of the adult chronic rhinosinusitis working definition. Am J Rhinol. 2002;16(1):7–10.
  31. Soler Zachary M., Mace Jess, Smith Timothy L., Symptom-based presentation of chronic rhinosinusitis and symptom-specific outcomes after endoscopic sinus surgery, 10.2500/ajr.2008.22.3172
  32. Nordin S., Monsch A. U., Murphy C., Unawareness of Smell Loss in Normal Aging and Alzheimer's Disease: Discrepancy between Self-Reported and Diagnosed Smell Sensitivity, 10.1093/geronb/50b.4.p187
  33. Welge-Luessen Antje, Psychophysical Effects of Nasal and Oral Inflammation, 10.1111/j.1749-6632.2009.04370.x
  34. Reden J., Maroldt H., Fritz A., Zahnert T., Hummel T., A study on the prognostic significance of qualitative olfactory dysfunction, 10.1007/s00405-006-0157-0
  35. Apter Andrea J., Gent Janneane F., Frank Marion E., Fluctuating Olfactory Sensitivity and Distorted Odor Perception in Allergic Rhinitis, 10.1001/archotol.125.9.1005
  36. Alobid I, Cardelus S, Benítez P, Guilemany JM, Roca-Ferrer J, Picado C, et al. Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis. Rhinology. 2011;49(5):519–24.
  37. Guilemany José Maria, Mariño-Sánchez Franklin Santiago, Angrill Joaquim, Alobid Isam, Centellas Silvia, Pujols Laura, Berenguer Joan, Bernal-Sprekelsen Manuel, Picado César, Mullol Joaquim, The importance of smell in patients with bronchiectasis, 10.1016/j.rmed.2010.10.019
  38. Litvack Jamie R., Mace Jess C., Smith Timothy L., Olfactory function and disease severity in chronic rhinosinusitis, 10.2500/ajra.2009.23.3286
  39. Alt Jeremiah A., Mace Jess C., Buniel Maria C. F., Soler Zachary M., Smith Timothy L., Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test : Predictors of Olfaction Using the BSIT, 10.1002/lary.24587
  40. Chang H., Lee H. J., Mo J.-H., Lee C. H., Kim J.-W., Clinical Implication of the Olfactory Cleft in Patients With Chronic Rhinosinusitis and Olfactory Loss, 10.1001/archoto.2009.140
  41. Rombaux Philippe, Potier Helene, Bertrand Bernard, Duprez Thierry, Hummel Thomas, Olfactory bulb volume in patients with sinonasal disease, 10.2500/ajr.2008.22.3237
  42. Vento Seija I., Simola Markku, Ertama Liisa O., Malmberg C. Henrik O., Sense of Smell in Long-Standing Nasal Polyposis, 10.2500/105065801779954229
  43. Mott A. E., Cain W. S., Lafreniere D., Leonard G., Gent J. F., Frank M. E., Topical Corticosteroid Treatment of Anosmia Associated With Nasal and Sinus Disease, 10.1001/archotol.1997.01900040009001
  44. Reychler Gregory, Colbrant Coralie, Huart Caroline, Le Guellec Sandrine, Vecellio Laurent, Liistro Giuseppe, Rombaux Philippe, Effect of three-drug delivery modalities on olfactory function in chronic sinusitis : Modalities of Corticosteroids Delivery in Rhinosinusitis, 10.1002/lary.24937
  45. Downey Laura L., Jacobs Joseph B., Lebowitz Richard A., Anosmia and Chronic Sinus Disease, 10.1016/s0194-5998(96)70131-6
  46. Delank KW, Stoll W. Olfactory function after functional endoscopic sinus surgery for chronic sinusitis. Rhinology. 1998;36(1):15–9.
  47. Klimek Ludger, Moll Bertram, Amedee Ronald G., Mann Wolf J., Olfactory Function After Microscopic Endonasal Surgery in Patients With Nasal Polyps, 10.2500/105065897781446621
  48. Min Yang-Gi, Yun Yeong-Seok, Song Byeong Ho, Cho Yang Sun, Lee Kang Soo, Recovery of Nasal Physiology after Functional Endoscopic Sinus Surgery: Olfaction and Mucociliary Transport, 10.1159/000276755
  49. Briner HR, Jones N, Simmen D. Olfaction after endoscopic sinus surgery: long-term results. Rhinology. 2012;50(2):178–84.
  50. Oka Hideki, Tsuzuki Kenzo, Takebayashi Hironori, Kojima Yusuke, Daimon Takashi, Sakagami Masafumi, Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis, 10.1016/j.anl.2012.12.001
  51. Litvack Jamie R., Mace Jess, Smith Timothy L., Does olfactory function improve after endoscopic sinus surgery?, 10.1016/j.otohns.2008.12.006
  52. Vandenhende-Szymanski C, Hochet B, Chevalier D, Mortuaire G. Olfactory cleft opacity and CT score are predictive factors of smell recovery after surgery in nasal polyposis. Rhinology. 2015;53(1):29–34.
  53. Cantone Elena, Maione Nunzia, Di Rubbo Vittoria, Esposito Fabrizio, Iengo Maurizio, Olfactory performance after Crenotherapy in chronic rhinosinusitis in the elderly : Crenotherapy and Olfactory Recovery, 10.1002/lary.25173
  54. Minwegen F, Thomas JP, Bernal-Sprekelsen M, Dazert S, Minovi A. Predictive value of disease severity on self-reported rating and quantitative measures of olfactory function outcomes after primary endoscopic sinus surgery. A prospective study. Rhinology. 2014;52(4):437–43.
  55. Kim Dae Woo, Kim Jin-Yong, Kim Sang-Wook, Jeon Sea-Yuong, Postoperative Olfactory Results in Chronic Rhinosinusitis with Nasal Polyposis According to Wound Healing Status, 10.3342/ceo.2013.6.3.146
  56. Hsu Chao-Yuan, Wang Ying-Piao, Shen Ping-Hung, Weitzel Erik Kent, Lai Jen-Tsung, Wormald Peter-John, Objective olfactory outcomes after revision endoscopic sinus surgery, 10.2500/ajra.2013.27.3939
  57. Baradaranfar Mohammad Hossein, Ahmadi Zeynab Sadat, Dadgarnia Mohammad Hossein, Bemanian Mohammad Hossein, Atighechi Saeid, Karimi Ghasem, Halvani Abolhasan, Behniafard Nasim, Baradaranfar Amin, Meybodi Tohid Emami, Comparison of the effect of endoscopic sinus surgery versus medical therapy on olfaction in nasal polyposis, 10.1007/s00405-013-2553-6
  58. DeConde Adam S., Mace Jess C., Alt Jeremiah A., Soler Zachary M., Orlandi Richard R., Smith Timothy L., Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management : Cardinal symptom improvement in CRS treatment, 10.1002/alr.21410
  59. Doty RL, Frye R. Influence of nasal obstruction on smell function. Otolaryngol Clin N Am. 1989;22(2):397–411.
  60. Kern Robert C., Candidate's Thesis: Chronic Sinusitis and Anosmia: Pathologic Changes in the Olfactory Mucosa : Candidate's Thesis: Chronic Sinusitis and Anosmia: Pathologic Changes in the Olfactory Mucosa, 10.1097/00005537-200007000-00001
  61. Naessen R., An Enquiry on the Morphological Characteristics and Possible Changes with Age in the Olfactory Region of Man, 10.3109/00016487109125332
  62. Getchell ML, Mellert T. Olfactory mucus secretion. In: Getchell TV, Bartoshuk LM, Doty RL, Snow Jr JB, editors. Smell and taste in health and disease. New York: Raven; 1991. p. 83–95.
  63. Hellings PW, Rombaux P. Medical therapy and smell dysfunction. B-ENT. 2009;5 Suppl 13:71–5.
  64. Joshi Hemant, Getchell Marilyn L., Zielinski Barbara, Getchell Thomas V., Spectrophotometric determination of cation concentrations in olfactory mucus, 10.1016/0304-3940(87)90276-x
  65. Kern Robert C., Foster James D., Pitovski Dimitri Z., Glucocorticoid (Type II) Receptors in the Olfactory Mucosa of the Guinea-Pig: RU 28362, 10.1093/chemse/22.3.313
  66. Apter Andrea J., Mott April E., Cain William S., Spiro Jeffrey D., Barwick Morven C., Olfactory loss and allergic rhinitis, 10.1016/0091-6749(92)90141-n
  67. Calof Anne L., Hagiwara Nobuko, Holcomb J. David, Mumm Jeffrey S., Shou Jianyong, Neurogenesis and cell death in olfactory epithelium, 10.1002/(sici)1097-4695(199605)30:1<67::aid-neu7>3.0.co;2-e
  68. Calof AL, Holcomb JD, Mumm JS, Haglwara N, Tran P, Smith KM, et al. Factors affecting neuronal birth and death in the mammalian olfactory epithelium. Ciba Found Symp. 1996;196:188–205. discussion; −10.
  69. Nakashima Tadashi, Kimmelman Charles P., Snow James B., IMMUNOHISTOPATHOLOGY OF HUMAN OLFACTORY EPITHELIUM, NERVE AND BULB : , 10.1288/00005537-198504000-00004
  70. Rombaux Philippe, Mouraux Andr??, Bertrand Bernard, Nicolas Georges, Duprez Thierry, Hummel Thomas, Olfactory Function and Olfactory Bulb Volume in Patients with Postinfectious Olfactory Loss : , 10.1097/01.mlg.0000195291.36641.1e
  71. Rombaux Philippe, Mouraux Andr??, Bertrand Bernard, Nicolas Georges, Duprez Thierry, Hummel Thomas, Retronasal and Orthonasal Olfactory Function in Relation to Olfactory Bulb Volume in Patients With Posttraumatic Loss of Smell : , 10.1097/01.mlg.0000217533.60311.e7
  72. Huart C., Eloy Ph., Collet S., Rombaux Ph., Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis, 10.1007/s00405-011-1670-3
  73. Dietz de Loos Dirk A. E., Hopkins Claire, Fokkens Wytske J., Symptoms in chronic rhinosinusitis with and without nasal polyps : Symptoms in CRS With and Without NP, 10.1002/lary.23671
  74. Br??merson Annika, Johansson Leif, Ek Lars, Nordin Steven, Bende Mats, Prevalence of Olfactory Dysfunction: The Sk??vde Population-Based Study : , 10.1097/00005537-200404000-00026
  75. Hox V, Bobic S, Callebaux I, Jorissen M, Hellings PW. Nasal obstruction and smell impairment in nasal polyp disease: correlation between objective and subjective parameters. Rhinology. 2010;48(4):426–32.
  76. Joe Stephanie A., Thakkar Kunal, Chronic Rhinosinusitis and Asthma, 10.1016/j.otc.2007.11.001
  77. Dunlop Gillian, Scadding Glenis K, Lund Valerie J., The Effect of Endoscopic Sinus Surgery on Asthma: Management of Patients With Chronic Rhinosinusitis, Nasal Polyposis, and Asthma, 10.2500/105065899782102809
  78. Perry Brian F, Kountakis Stilianos E, Subjective improvement of olfactory function after endoscopic sinus surgery for chronic rhinosinusitis, 10.1016/s0196-0709(03)00067-x
  79. Landis Basile N., Giger Roland, Ricchetti Alma, Leuchter Igor, Hugentobler Marianne, Hummel Thomas, Lacroix Jean-Silvain, Retronasal olfactory function in nasal polyposis, 10.1097/00005537-200311000-00026
  80. Pfaar Oliver, Landis Basile Nicolas, Frasnelli Johannes, Hüttenbrink Karl-Bernd, Hummel Thomas, Mechanical Obstruction of the Olfactory Cleft Reveals Differences Between Orthonasal and Retronasal Olfactory Functions, 10.1093/chemse/bjj002
  81. Konstantinidis Iordanis, Triaridis Stefanos, Printza Athanasia, Vital Victor, Ferekidis Eleftherios, Constantinidis Jannis, Olfactory Dysfunction in Nasal Polyposis: Correlation with Computed Tomography Findings, 10.1159/000101543
  82. Blomqvist Ebba Hedén, Lundblad Lars, Bergstedt Hans, Stjärne Pär, Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia, 10.1080/00016480310002140
  83. Lund VJ, MacKay IS. Outcome assessment of endoscopic sinus surgery. J R Soc Med. 1994;87(2):70–2.
  84. Levine Howard L., Functional Endoscopic Sinus Surgery : Evaluation, Surgery, and Follow-up of 250 Patients, 10.1288/00005537-199001000-00016
  85. Miwa Takaki, Furukawa Mitsuru, Tsukatani Toshiaki, Costanzo Richard M., DiNardo Laurence J., Reiter Evan R., Impact of Olfactory Impairment on Quality of Life and Disability, 10.1001/archotol.127.5.497
  86. Heilmann S, Huettenbrink KB, Hummel T. Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol. 2004;18(1):29–33.
  87. Bonfils Pierre, Halimi Philippe, Malinvaud David, Adrenal suppression and osteoporosis after treatment of nasal polyposis, 10.1080/00016480600672667
  88. Jakobsen John, Functional Endoscopic Sinus Surgery in Chronic Sinusitis - a Series of 237 Consecutively Operated Patients, 10.1080/000164800454279
  89. Klossek Jean-Michel, Peloquin Louis, Friedman William H., Ferrier Jean-Claude, Fontanel Jean-Pierre, Diffuse Nasal Polyposis: Postoperative Long-Term Results after Endoscopic Sinus Surgery and Frontal Irrigation, 10.1016/s0194-5998(97)70126-8
  90. Park AH, Lau J, Stankiewicz J, Chow J. The role of functional endoscopic sinus surgery in asthmatic patients. J Otolaryngol. 1998;27(5):275–80.
  91. Lund VJ, Scadding GK. Objective assessment of endoscopic sinus surgery in the management of chronic rhinosinusitis: an update. J Laryngol Otol. 1994;108(9):749–53.
  92. Rudmik Luke, Smith Timothy L., Olfactory improvement after endoscopic sinus surgery : , 10.1097/moo.0b013e32834dfb3d
  93. Bonfils P, Malinvaud D, Soudry Y, Devars du Maine M, Laccourreye O. Surgical therapy and olfactory function. B-ENT. 2009;5 Suppl 13:77–87.
  94. Soler Zachary M., Sauer David A., Mace Jess C., Smith Timothy L., Ethmoid histopathology does not predict olfactory outcomes after endoscopic sinus surgery, 10.2500/ajra.2010.24.3477
  95. Wright Erin D., Agrawal Sumit, Impact of Perioperative Systemic Steroids on Surgical Outcomes in Patients With Chronic Rhinosinusitis With Polyposis: Evaluation With the Novel Perioperative Sinus Endoscopy (POSE) Scoring System, 10.1097/mlg.0b013e31814842f8
  96. Jiang Rong-San, Su Mao-Chang, Liang Kai-Li, Shiao Jiun-Yih, Hsin Chung-Han, Lu Fung-Jou, Chen Wen-Kang, Preoperative prognostic factors for olfactory change after functional endoscopic sinus surgery, 10.2500/ajra.2009.23.3262
  97. Bhattacharyya Neil, Radiographic Stage Fails to Predict Symptom Outcomes after Endoscopic Sinus Surgery for Chronic Rhinosinusitis : , 10.1097/01.mlg.0000192284.22703.04
  98. Jankowski R, Bodino C. Olfaction in patients with nasal polyposis: effects of systemic steroids and radical ethmoidectomy with middle turbinate resection (nasalization). Rhinology. 2003;41(4):220–30.
  99. Jankowski Roger, Pigret Damien, Decroocq Frederic, Comparison of Functional Results after Ethmoidectomy and Nasalization for Diffuse and Severe Nasal Polyposis, 10.3109/00016489709113445
  100. Konstantinidis Iordanis, Tsakiropoulou Evangelia, Bekiaridou Paschalia, Kazantzidou Chrysa, Constantinidis Jannis, Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction : Olfactory Training Short-Term Effect, 10.1002/lary.24390
  101. Hummel Thomas, Rissom Karo, Reden Jens, Hähner Aantje, Weidenbecher Mark, Hüttenbrink Karl-Bernd, Effects of olfactory training in patients with olfactory loss, 10.1002/lary.20101
  102. Damm Michael, Pikart Louisa K., Reimann Heike, Burkert Silke, Göktas Önder, Haxel Boris, Frey Sabine, Charalampakis Ioannis, Beule Achim, Renner Berthold, Hummel Thomas, Hüttenbrink Karl-Bernd, Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study : Olfactory Training, 10.1002/lary.24340
Bibliographic reference Rombaux, Philippe ; Huart, Caroline ; Levie, P ; Cinqi, C ; Hummel, T. Olfaction in Chronic Rhinosinusitis. In: Rhinosinusitis - Current Allergy and Asthma Reports, Vol. 16, no.5, p. 41 (May 2016)
Permanent URL http://hdl.handle.net/2078.1/174351