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When polymerase chain reaction does not help: cytomegalovirus pneumonitis associated with very low or undetectable viral load in both blood and bronchoalveolar lavage samples after lung transplantation.

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Coussement, Julien Steensels, Deborah Nollevaux, Marie-Cécile [UCL] Bogaerts, Pierre [UCL] Dumonceaux, Michel [UCL] Delaere, Bénédicte [UCL] Froidure, Antoine [UCL]

Cytomegalovirus (CMV) pneumonitis occurs frequently among solid organ transplant recipients and is classically associated with significant viral replication in both blood and bronchoalveolar lavage (BAL) samples. We present a case of a 64-year-old lung transplant recipient who presented with CMV pneumonitis that was diagnosed based on the association of viral inclusion in the BAL sample, rapid response to ganciclovir, and absence of other infectious etiology. Surprisingly, we observed very low or undetectable viral load both in blood and BAL samples. Diagnosis of CMV pneumonitis should rely on the association of clinical, pathological, radiological, and microbiological signs, while quantitative nucleic acid amplification testing should be interpreted with caution.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Transplant Infectious Disease" - Vol. 18, no. 2, p. 284-287 (2016)
Peer reviewed yes
Publisher Munksgaard ((Denmark) Copenhagen)
issn 1398-2273
e-issn 1399-3062
Publication status Publié
Affiliations UCL - (MGD) Laboratoire de biologie clinique
UCL - (MGD) Service d'anatomie pathologique
UCL - (MGD) Service de pneumologie
UCL - (MGD) Pathologie infectieuse
UCL - (SLuc) Service de pneumologie
UCL - SSS/IREC/MORF - Pôle de Morphologie
UCL - SSS/IREC/MONT - Pôle Mont Godinne
Keywords Cytomegalovirus ; Lung transplantation ; Nucleic acid amplification testing ; Pneumonitis ; Polymerase chain reaction ; Viral load
Links
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Bibliographic reference Coussement, Julien ; Steensels, Deborah ; Nollevaux, Marie-Cécile ; Bogaerts, Pierre ; Dumonceaux, Michel ; et. al. When polymerase chain reaction does not help: cytomegalovirus pneumonitis associated with very low or undetectable viral load in both blood and bronchoalveolar lavage samples after lung transplantation.. In: Transplant Infectious Disease, Vol. 18, no. 2, p. 284-287 (2016)
Permanent URL http://hdl.handle.net/2078.1/173510