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Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

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De Bree, Remco Takes, Robert P. Castelijns, Jonas A. Medina, Jesus E. Stoeckli, Sandro J. Hamoir, Marc [UCL] Ferlito, Alfio

(eng) Regional metastasis is a prominent feature of head and neck squamous cell carcinoma (HNSCC) and is an important prognostic factor. The currently available imaging techniques for assessment of the neck have limitations in accuracy; thus, elective neck dissection has remained the usual choice of management of the clinically N0 neck (cN0) for tumors with significant (≥20%) incidence of occult regional metastasis. As a consequence, the majority of patients without regional metastasis will undergo unnecessary treatment. The purpose of this review was to discuss new developments in techniques that potentially improve the accuracy of the assessment of the neck in patients with HNSCC. Although imaging has improved in the last decades, a limitation common to all imaging techniques is a lack of sensitivity for small tumor deposits. Therefore, complementary to improvements in imaging techniques, developments in more invasive diagnostic procedures, such as sentinel node biopsy (SNB) will add to the accuracy of diagnostic algorithms for the staging of the neck.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Head & Neck : journal for the sciences and specialities of the head and neck" - Vol. 37, no. 12, p. 1829-1839 (2015)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) New York, NY)
issn 1043-3074
e-issn 1097-0347
Publication status Publié
Affiliations UCL - (SLuc) Service d'oto-rhino-laryngologie
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
Keywords Diagnostic techniques ; Head and neck ; Lymph node metastasis ; Occult ; Squamous cell carcinoma
Links
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Bibliographic reference De Bree, Remco ; Takes, Robert P. ; Castelijns, Jonas A. ; Medina, Jesus E. ; Stoeckli, Sandro J. ; et. al. Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma. In: Head & Neck : journal for the sciences and specialities of the head and neck, Vol. 37, no. 12, p. 1829-1839 (2015)
Permanent URL http://hdl.handle.net/2078.1/172143