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Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

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Topalovic, Marko Derom, Eric Osadnik, Christian R. Troosters, Thierry Decramer, Marc Collard, Philippe [UCL] Liistro, Giuseppe [UCL] Mwenge, Gimbada Benny [UCL] Pieters, Thierry [UCL] Pilette, Charles [UCL] Pirson, Françoise [UCL] Delaunois, Luc [UCL] Marchand, Eric [UCL] Vandenplas, Olivier [UCL] Rodenstein, Daniel [UCL]

BACKGROUND: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. METHODS: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). RESULTS: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. CONCLUSIONS: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Respiratory Research" - Vol. 16, no. 1, p. 88 [1-8] (2015)
Peer reviewed yes
Publisher BioMed Central Ltd. ((United Kingdom) London)
issn 1465-9921
e-issn 1465-993X
Affiliations UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - (SLuc) Service de pneumologie
UCL - (MGD) Service de pneumologie
Links
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Bibliographic reference Topalovic, Marko ; Derom, Eric ; Osadnik, Christian R. ; Troosters, Thierry ; Decramer, Marc ; et. al. Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. In: Respiratory Research, Vol. 16, no. 1, p. 88 [1-8] (2015)
Permanent URL http://hdl.handle.net/2078.1/172068