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Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.

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Kroksveen, Ann [University of Bergen, Norway] Jaffe, Jacob D [Broad Institute of MIT and Harvard, Cambridge, USA] Aasebo, Elise [University of Bergen, Norway] Barsnes, Harald [University of Bergen, Norway] Bjorlykke, Yngvild [University of Bergen, Norway] Van Pesch, Vincent [UCL] Berven, Frode S. [University of Bergen, Bergen, Norway]

Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with unknown cause. Proteins with different abundance in the cerebrospinal fluid (CSF) from relapsing-remitting MS (RRMS) patients and neurological controls could give novel insight to the MS pathogenesis and be used to improve diagnosis, predict prognosis and disease course, and guide in therapy decisions. We combined iTRAQ labeling and Orbitrap mass spectrometry to discover proteins with different CSF abundance between six RRMS patients and 18 neurological disease controls. From 777 quantified proteins seven were selected as biomarker candidates, namely chitinase-3-like protein 1, secretogranin-1 (Sg1), cerebellin-1, neuroserpin, cell surface glycoprotein MUC18, testican-2 and glutamate receptor 4. An independent sample set of 13 early-MS patients, 13 RRMS patients and 13 neurological controls was used in a multiple reaction monitoring verification study. We found the intracellular calcium binding protein Sg1 to be increased in early-MS patients compared to RRMS and neurological controls. Sg1 should be included in further studies to elucidate its role in the early phases of MS pathogenesis and its potential as a biomarker for this disease. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Proteomics" - Vol. 15, p. 3361-3369 (2015)
Peer reviewed yes
Publisher Wiley - V C H Verlag GmbH & Co. KGaA ((Germany) Weinheim)
issn 1615-9853
e-issn 1615-9861
Publication status Publié
Affiliations UCL - (SLuc) Service de neurologie
UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Keywords Biomarkers ; Biomedicine ; Cerebrospinal fluid ; Multiple sclerosis ; Quantitative mass spectrometry ; Secretogranin-1
Links
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Bibliographic reference Kroksveen, Ann ; Jaffe, Jacob D ; Aasebo, Elise ; Barsnes, Harald ; Bjorlykke, Yngvild ; et. al. Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.. In: Proteomics, Vol. 15, p. 3361-3369 (2015)
Permanent URL http://hdl.handle.net/2078.1/172002