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Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications

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Pineux, F. [UNamur] Marega, R. [UNamur] Stopin, A. [UNamur] La Torre, A. [University of Nottingham (UK)] Garcia, Yann [UCL] Michiels, C. [UNamur] Bonifazi, D. [UNamur]

Fe-filled carbon nanotubes (Fe@CNTs) recently emerged as an effective class of hybrid nanoparticles for biotechnological applications, such as magnetic cell sorting and magnetic fluid hyperthermia. Aiming at studying the effects of both the Fe loading and the magnetocrystalline characteristics in these applications, we describe herein the preparation of Fe@CNTs containing different Fe phases that, upon functionalization with the antibody Cetuximab (Ctxb), allow the targeting of cancer cells. Our experimental findings reveal that an optimal Ctxb/Fe weight ratio of 1.2 is needed for efficient magnetic cell shepherding, whereas enhanced MFH-induced mortality (70 vs. 15%) can be reached with hybrids enriched in the coercive Fe3C phase. These results suggest that a synergistic effect between the Ab loading and the Fe distribution in each nanotube exists, for which the maximum shepherding and hyperthermia effects are observed when higher densities of Fe@CNTs featuring the more coercive phase are interfaced with the cells.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Nanoscale" - Vol. 7, p. 20474-20488 (2015)
Peer reviewed yes
Publisher Royal Society of Chemistry
issn 2040-3364
Publication status Publié
Affiliation UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity
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Bibliographic reference Pineux, F. ; Marega, R. ; Stopin, A. ; La Torre, A. ; Garcia, Yann ; et. al. Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications. In: Nanoscale, Vol. 7, p. 20474-20488 (2015)
Permanent URL http://hdl.handle.net/2078.1/171414