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Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease.

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Pierrot, Nathalie [UCL] Lhommel, Renaud [UCL] Quenon, Lisa [UCL] Hanseeuw, Bernard [UCL] Dricot, Laurence [UCL] Sindic, Christian [UCL] Maloteaux, Jean-Marie [UCL] Octave, Jean-Noël [UCL] Ivanoiu, Adrian [UCL]

We present the effects of Targretin® (bexarotene) on cognition and biomarkers in a patient with mild Alzheimer's disease (AD). Targretin® is a Retinoic X Receptor (RXR) agonist shown to improve synaptic and cognitive functions in animal models of AD by increasing neuronal cholesterol efflux. After 6 months of treatment with Targretin® 300 mg/day, memory improved by about 40% and the tau protein in the cerebrospinal fluid decreased by about 20% . No significant side effects were noticed. This observation in a single patient indicates that Targretin® may improve memory performance and biological markers at an early stage of AD.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Journal of Alzheimer's Disease" - Vol. 49, no. 2, p. 271-276 (2016)
Peer reviewed yes
Publisher IOS Press ((Netherlands) Amsterdam)
issn 1387-2877
e-issn 1875-8908
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - SSS/IRSS - Institut de recherche santé et société
UCL - (SLuc) Service de médecine nucléaire
UCL - (SLuc) Service de neurologie
Links
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Bibliographic reference Pierrot, Nathalie ; Lhommel, Renaud ; Quenon, Lisa ; Hanseeuw, Bernard ; Dricot, Laurence ; et. al. Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease.. In: Journal of Alzheimer's Disease, Vol. 49, no. 2, p. 271-276 (2016)
Permanent URL http://hdl.handle.net/2078.1/170016