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Mite allergen-specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin.

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Mouthuy, Jonathan [UCL] Viart, Sophie [UCL] Ladjemi, Maha [UCL] Detry, Bruno [UCL] Henket, monique [Université de Liège] Pilette, Charles [UCL]

(eng) IgE is synthesized locally, in the bronchial mucosa, in both atopic and non-atopic asthma. The present study of bronchial secretions from asthma patients confirms that part of this IgE is specific to house dust mite (Dermatophagoïdes pteronyssinus) allergens, irrespective of atopy. In addition, it reveals that this IgE response correlates with periostin, but not to eosinophils, in sputum from these patients, probably in relation to their common IL-4/IL-13 triggering pathway.

Document type Article de périodique (Journal article) – Lettre à l'éditeur
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Journal of Allergy and Clinical Immunology" - Vol. 136, no. 6, p. 1685-1688.e2 (2015)
Peer reviewed yes
Publisher Mosby, Inc. ((United States) St-Louis, MI)
issn 0091-6749
e-issn 1097-6825
Publication status Publié
Affiliations UCL - SSS/IREC/PNEU-Pôle de Pneumologie, ORL et Dermatologie
UCL - (SLuc) Service de pneumologie
UCL - (SLuc) Autre
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Bibliographic reference Mouthuy, Jonathan ; Viart, Sophie ; Ladjemi, Maha ; Detry, Bruno ; Henket, monique ; et. al. Mite allergen-specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin.. In: Journal of Allergy and Clinical Immunology, Vol. 136, no. 6, p. 1685-1688.e2 (2015)
Permanent URL http://hdl.handle.net/2078.1/165882