User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4(+) T Cells with Apoptosis-Inducing Properties.

Primary tabs

download
  • Open access
  • PDF
  • 113.13 K
Malek Abrahimians, Elin [UCL] Carlier, Vincent A Vander Elst, Luc Saint-Remy, Jean-Marie R

Abrogating an unwanted immune response toward a specific antigen without compromising the entire immune system is a hoped-for goal in immunotherapy. Instead of manipulating dendritic cells and suppressive regulatory T cells, depleting effector T cells or blocking their co-stimulatory pathways, we describe a method to specifically inhibit the presentation of an antigen eliciting an unwanted immune reaction. Inclusion of an oxidoreductase motif within the flanking residues of MHC class II epitopes polarizes CD4(+) T cells to cytolytic cells capable of inducing apoptosis in antigen presenting cells (APCs) displaying cognate peptides through MHC class II molecules. This novel function results from an increased synapse formation between both cells. Moreover, these cells eliminate by apoptosis bystander CD4(+) T cells activated at the surface of the APC. We hypothesize that they would thereby block the recruitment of cells of alternative specificity for the same autoantigen or cells specific for another antigen associated with the pathology, providing a system by which response against multiple antigens linked with the same disease can be suppressed. These findings open the way toward a novel form of antigen-specific immunosuppression.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Frontiers in Immunology" - Vol. 6, no.0, p. 449 (2015)
Publisher Frontiers Research Foundation
issn 1664-3224
e-issn 1664-3224
Affiliations UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - (SLuc) Service de pédiatrie spécialisée
Links
  1. Garcia-Chagollan Mariel, Jave-Suarez Luis F, Haramati Jesse, Sanchez-Hernandez Pedro E, Aguilar-Lemarroy Adriana, Bueno-Topete Miriam R, Pereira-Suarez Ana L, Fafutis-Morris Mary, Cid-Arregui Angel, del Toro-Arreola Susana, Substantial increase in the frequency of circulating CD4+NKG2D+ T cells in patients with cervical intraepithelial neoplasia grade 1, 10.1186/1423-0127-20-60
  2. Fleischer Bernhard, Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture, 10.1038/308365a0
  3. Gromkowski Stanislaw H., Hepler Kristin M., Janeway Charles A., Low doses of interleukin 2 induce bystander cell lysis by antigen-specific CD4 inflammatory T cell clones in short-term assay, 10.1002/eji.1830180913
  4. Adhikary Dinesh, Behrends Uta, Moosmann Andreas, Witter Klaus, Bornkamm Georg W., Mautner Josef, Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins, 10.1084/jem.20051287
  5. Strutt Tara M, McKinstry K Kai, Dibble John P, Winchell Caylin, Kuang Yi, Curtis Jonathan D, Huston Gail, Dutton Richard W, Swain Susan L, Memory CD4+ T cells induce innate responses independently of pathogen, 10.1038/nm.2142
  6. Brown Deborah M., Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy, 10.1016/j.cellimm.2010.02.008
  7. Woodland David L, Hogan R Jeffrey, Zhong Weimin, Cellular Immunity and Memory to Respiratory Virus Infections, 10.1385/ir:24:1:53
  8. Tsuji M., CD4+ cytolytic T cell clone confers protection against murine malaria, 10.1084/jem.172.5.1353
  9. Perez-Diez A., Joncker N. T., Choi K., Chan W. F. N., Anderson C. C., Lantz O., Matzinger P., CD4 cells can be more efficient at tumor rejection than CD8 cells, 10.1182/blood-2006-10-051318
  10. Appay V., Zaunders J. J., Papagno L., Sutton J., Jaramillo A., Waters A., Easterbrook P., Grey P., Smith D., McMichael A. J., Cooper D. A., Rowland-Jones S. L., Kelleher A. D., Characterization of CD4+ CTLs Ex Vivo, 10.4049/jimmunol.168.11.5954
  11. HAHN SINUHE, GEHRI ROLAND, ERB PETER, Mechanism and Biological Significance of CD4-mediated Cytotoxicity, 10.1111/j.1600-065x.1995.tb00684.x
  12. Cheroutre Hilde, Husain Mohammad Mushtaq, CD4 CTL: Living up to the challenge, 10.1016/j.smim.2013.10.022
  13. Soghoian Damien Z, Streeck Hendrik, Cytolytic CD4+T cells in viral immunity, 10.1586/erv.10.132
  14. von Herrath Matthias G., Harrison Leonard C., Regulatory Lymphocytes: Antigen-induced regulatory T cells in autoimmunity, 10.1038/nri1029
  15. Knoechel B., Lohr J., Zhu S., Wong L., Hu D., Ausubel L., Abbas A. K., Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes, 10.4049/jimmunol.176.11.6473
  16. Liu Weihong, Putnam Amy L., Xu-yu Zhou, Szot Gregory L., Lee Michael R., Zhu Shirley, Gottlieb Peter A., Kapranov Philipp, Gingeras Thomas R., de St. Groth Barbara Fazekas, Clayberger Carol, Soper David M., Ziegler Steven F., Bluestone Jeffrey A., CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+T reg cells, 10.1084/jem.20060772
  17. Sakaguchi Shimon, Sakaguchi Noriko, Shimizu Jun, Yamazaki Sayuri, Sakihama Toshiko, Itoh Misako, Kuniyasu Yuhshi, Nomura Takashi, Toda Masaaki, Takahashi Takeshi, Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance, 10.1034/j.1600-065x.2001.1820102.x
  18. Bluestone Jeffrey A., Opinion: Regulatory T-cell therapy: is it ready for the clinic?, 10.1038/nri1574
  19. Anderson Per O., Manzo Barbara A., Sundstedt Anette, Minaee Sophie, Symonds Alistair, Khalid Sabah, Rodriguez-Cabezas Maria E., Nicolson Kirsty, Li Suling, Wraith David C., Wang Ping, Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance, 10.1002/eji.200635883
  20. Verhoef Adrienne, Alexander Clare, Kay A. Barry, Larché Mark, T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity, 10.1371/journal.pmed.0020078
  21. Veldhoen Marc, Hocking Richard J., Atkins Christopher J., Locksley Richard M., Stockinger Brigitta, TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells, 10.1016/j.immuni.2006.01.001
  22. Akbari Omid, Freeman Gordon J., Meyer Everett H., Greenfield Edward A., Chang Tammy T., Sharpe Arlene H., Berry Gerald, DeKruyff Rosemarie H., Umetsu Dale T., Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity, 10.1038/nm745
  23. Cobbold Stephen P., The hidden truth about gene expression in Tregs: Is it what you don't see that counts?, 10.1002/eji.200636171
  24. Lovitch S. B., Pu Z., Unanue E. R., Amino-Terminal Flanking Residues Determine the Conformation of a Peptide-Class II MHC Complex, 10.4049/jimmunol.176.5.2958
  25. Purvis H. A., Stoop J. N., Mann J., Woods S., Kozijn A. E., Hambleton S., Robinson J. H., Isaacs J. D., Anderson A. E., Hilkens C. M. U., Low-strength T-cell activation promotes Th17 responses, 10.1182/blood-2010-03-272153
  26. Carson Richard T., Vignali Kate M., Woodland David L., Vignali Dario A.A., T Cell Receptor Recognition of MHC Class II–Bound Peptide Flanking Residues Enhances Immunogenicity and Results in Altered TCR V Region Usage, 10.1016/s1074-7613(00)80360-x
  27. Holland Christopher J., Cole David K., Godkin Andrew, Re-Directing CD4+ T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough, 10.3389/fimmu.2013.00172
  28. Wu B., Elst L. V., Carlier V., Jacquemin M. G., Saint-Remy J.-M. R., The Dermatophagoides pteronyssinus Group 2 Allergen Contains a Universally Immunogenic T Cell Epitope, 10.4049/jimmunol.169.5.2430
  29. Janssens W., Carlier V., Wu B., VanderElst L., Jacquemin M. G., Saint-Remy J.-M. R., CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner, 10.4049/jimmunol.171.9.4604
  30. Meyer Yves, Buchanan Bob B., Vignols Florence, Reichheld Jean-Philippe, Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology, 10.1146/annurev-genet-102108-134201
  31. Schwertassek Ulla, Balmer Yves, Gutscher Marcus, Weingarten Lars, Preuss Marc, Engelhard Johanna, Winkler Monique, Dick Tobias P, Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1, 10.1038/sj.emboj.7601746
  32. Carlier, PLoS One, 7, e45366 (2012)
  33. Schmidt Bryan, Ho Lorraine, Hogg Philip J., Allosteric Disulfide Bonds†, 10.1021/bi0603064
  34. Anderson Robert P, Jabri Bana, Vaccine against autoimmune disease: antigen-specific immunotherapy, 10.1016/j.coi.2013.02.004
  35. Snow Andrew L., Pandiyan Pushpa, Zheng Lixin, Krummey Scott M., Lenardo Michael J., The power and the promise of restimulation-induced cell death in human immune diseases : RICD and T-cell homeostasis, 10.1111/j.1600-065x.2010.00917.x
  36. Nicholas, Discov Med, 11, 293 (2011)
  37. Prasad Suchitra, Kohm Adam P., McMahon Jeffrey S., Luo Xunrong, Miller Stephen D., Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading, 10.1016/j.jaut.2012.04.005
Bibliographic reference Malek Abrahimians, Elin ; Carlier, Vincent A ; Vander Elst, Luc ; Saint-Remy, Jean-Marie R. MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4(+) T Cells with Apoptosis-Inducing Properties.. In: Frontiers in Immunology, Vol. 6, no.0, p. 449 (2015)
Permanent URL http://hdl.handle.net/2078.1/165445