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Feasibility and robustness of dose painting by numbers in proton therapy with contour-driven plan optimization

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Barragan Montero, Ana Maria [UCL] Differding, Sarah [UCL] Janssens, G. Lee, John Aldo [UCL] Sterpin, Edmond [UCL]

Purpose: To prove the ability of protons to reproduce a dose gradient that matches a dose painting by numbers (DPBN) prescription in the presence of setup and range errors, by using contours and structure-based optimization in a commercial treatment planning system. Methods: For two patients with head and neck cancer, voxel-by-voxel prescription to the target volume (GTVPET) was calculated from 18FDG-PET images and approximated with several discrete prescription subcontours. Treatments were planned with proton pencil beam scanning. In order to determine the optimal plan parameters to approach the DPBN prescription, the e↵ects of the scanning pattern, number of fields, number of subcontours, and use of range shifter were separately tested on each patient. Di↵erent constant scanning grids (i.e., spot spacing = x = y = 3.5, 4, and 5 mm) and uniform energy layer separation [4 and 5 mm WED (water equivalent distance)] were analyzed versus a dynamic and automatic selection of the spots grid. The number of subcontours was increased from 3 to 11 while the number of beams was set to 3, 5, or 7. Conventional PTV-based and robust clinical target volumes (CTV)-based optimization strategies were considered and their robustness against range and setup errors assessed. Because of the nonuniform prescription, ensuring robustness for coverage of GTVPET inevitably leads to overdosing, which was compared for both optimization schemes. Results: The optimal number of subcontours ranged from 5 to 7 for both patients. All considered scanning grids achieved accurate dose painting (1% average di↵erence between the prescribed and planned doses). PTV-based plans led to nonrobust target coverage while robust-optimized plans improved it considerably (di↵erences between worst-case CTV dose and the clinical constraint was up to 3 Gy for PTV-based plans and did not exceed 1 Gy for robust CTV-based plans). Also, only 15% of the points in the GTVPET (worst case) were above 5% of DPBN prescription for robust-optimized plans, while they were more than 50% for PTV plans. Low dose to organs at risk (OARs) could be achieved for both PTV and robust-optimized plans. Conclusions: DPBN in proton therapy is feasible with the use of a sucient number subcontours, automatically generated scanning patterns, and no more than three beams are needed. Robust optimization ensured the required target coverage and minimal overdosing, while PTV-approach led to nonrobust plans with excessive overdose. Low dose to OARs can be achieved even in the presence of a high-dose escalation as in DPBN.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2015
Language Anglais
Journal information "Medical Physics" - Vol. 42, no.4, p. 2006-2017 (2015)
Peer reviewed yes
Publisher American Association of Physicists in Medicine
issn 0094-2405
Publication status Publié
Affiliation UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
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Bibliographic reference Barragan Montero, Ana Maria ; Differding, Sarah ; Janssens, G. ; Lee, John Aldo ; Sterpin, Edmond. Feasibility and robustness of dose painting by numbers in proton therapy with contour-driven plan optimization. In: Medical Physics, Vol. 42, no.4, p. 2006-2017 (2015)
Permanent URL http://hdl.handle.net/2078.1/164976