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Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation

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Manzia, Tommaso Maria Angelico, Roberta Toti, Luca Lai, Quirino [UCL] Ciano, Paolo Tisone, Giuseppe

HCV-related disease is the most common indication for liver transplantation (LT). HCV recurrence, which is almost universal, has a significant impact on patient and graft survival after LT and still represents a great unsolved issue for the liver transplant community. Several treatment strategies have been proposed. Since antiviral therapy has limited efficacy and can be administrated only in selected transplant recipients and additionally that immunosuppressive drugs have a negative impact on HCV re-infection, the achievement of an immunosuppression-free state after LT could play a central role in the avoidance of rapid HCV recurrence. © 2012 Expert Reviews Ltd.

Document type Article de périodique (Journal article) – Synthèse de littérature
Publication date 2012
Language Anglais
Journal information "Expert Review of Clinical Immunology" - Vol. 8, no. 7, p. 635-44 (2012)
Peer reviewed yes
Publisher Expert Reviews Ltd. ((United Kingdom) London)
issn 1744-666X
e-issn 1744-8409
Publication status Publié
Affiliation UCL - (SLuc) Service de chirurgie et transplantation abdominale
Links
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Bibliographic reference Manzia, Tommaso Maria ; Angelico, Roberta ; Toti, Luca ; Lai, Quirino ; Ciano, Paolo ; et. al. Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation. In: Expert Review of Clinical Immunology, Vol. 8, no. 7, p. 635-44 (2012)
Permanent URL http://hdl.handle.net/2078.1/164218