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Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives

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Leroux, Antoine Meunier, Stéphane Legall, Thierry Denis, Jean-Marc [UCL] Bischoff, Pierre Wagner, Alain

A high-throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton-like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell-based fluorescent assay, we show that some of these compounds have a pronounced ability to prevent cell death caused by radiation and to allow the subsequent resumption of proliferation. Thus, PADs may be considered as a novel class of radioprotective agents. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2011
Language Anglais
Journal information "ChemMedChem : chemistry enabling drug discovery" - Vol. 6, no. 3, p. 561-569 (2011)
Peer reviewed yes
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
e-issn 1860-7187
issn 1860-7179
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
Links
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Bibliographic reference Leroux, Antoine ; Meunier, Stéphane ; Legall, Thierry ; Denis, Jean-Marc ; Bischoff, Pierre ; et. al. Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives. In: ChemMedChem : chemistry enabling drug discovery, Vol. 6, no. 3, p. 561-569 (2011)
Permanent URL http://hdl.handle.net/2078.1/163530