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Method for the selective survival or selective growth of a target cell by the use of a conjugate, its use in therapeutics and/or diagnostics and the preparation of said conjugate

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Soumillion, Patrice [UCL] Fastrez, Jacques [UCL]

The invention is in particular related to a method for the selective survival or selective growth of a target cell comprising the steps of: a) contacting the target cell with a conjugate compound A-B, wherein A is a selective antibody or antibody derivative recognizing the target cell and B is a biotic agent able to at least partially inactivate an anti-bios agent, said anti-bios agent is able to inhibit the growth of cells; and b) contacting the target cell with the anti-bios agent.The present invention also relates to said conjugate on its own, a selection medium for cells comprising said conjugate and cells that are selected or recognised using a method or conjugate according to the present invention. The present invention further elucidates a pharmaceutical compound or composition, a kit for the detection of a target cell or for the diagnosis of diseases caused by the target cell or a product that can be used in the therapy of infectious related diseases comprising a conjugate according to present invention.

Document type Brevet (Patent)
Access type Accès libre
Publication date 2001
Language Anglais
Patent coverage International
Patent office BRANTS, Johan, Philippe, Emile; De Clercq, Brants & Partners E. Gevaertdreef 10 a B-9830 Sint-Martens-Latem (BE)
IPC A61K 47/48 (2006.01), C12N 9/80 (2006.01)
ECLA WO2001097854
Affiliations UCL - SST/ISV - Institut des sciences de la vie
UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology
Links
Bibliographic reference Soumillion, Patrice ; Fastrez, Jacques. Method for the selective survival or selective growth of a target cell by the use of a conjugate, its use in therapeutics and/or diagnostics and the preparation of said conjugate. (2001)
Permanent URL http://hdl.handle.net/2078.1/162097