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Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial).

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Brevoord, Daniel Hollmann, Markus W De Hert, Stefan G van Dongen, Eric Hpa Heijnen, Bram Gadh Momeni, Mona [UCL] Preckel, Benedikt

Pre- and postconditioning describe mechanisms whereby short ischemic periods protect an organ against a longer period of ischemia. Interestingly, short ischemic periods of a limb, in itself harmless, may increase the ischemia tolerance of remote organs, e.g. the heart (remote conditioning, RC). Although several studies have shown reduced biomarker release by RC, a reduction of complications and improvement of patient outcome still has to be demonstrated. Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass graft surgery (CABG), affecting 27-46% of patients. It is associated with increased mortality, adverse cardiovascular events, and prolonged in-hospital stay. We hypothesize that remote ischemic pre- and/or post-conditioning reduce the incidence of AF following CABG, and improve patient outcome.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "BMC Anesthesiology" - Vol. 11, no. 1, p. 11 (2011)
Peer reviewed yes
Publisher BioMed Central Ltd. (London)
issn 1471-2253
e-issn 1471-2253
Publication status Publié
Affiliations UCL - (SLuc) Service d'anesthésiologie
UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
Links
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Bibliographic reference Brevoord, Daniel ; Hollmann, Markus W ; De Hert, Stefan G ; van Dongen, Eric Hpa ; Heijnen, Bram Gadh ; et. al. Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial).. In: BMC Anesthesiology, Vol. 11, no. 1, p. 11 (2011)
Permanent URL http://hdl.handle.net/2078.1/161353