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Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype

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Matic, Maja Simons, Sinno H.P. Van Lingen, Richard A. Van Rosmalen, Joost Elens, Laure [UCL] Van Schaik, Ron H.N.

Aim: Determine whether SNPs of OPRM1 118A>G (asn40asp), COMT 472G>A (val158met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. Materials & methods: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue morphine was documented. Results: For OPRM1 and COMT separately, the expected risk for rescue morphine or morphine dose was not significantly increased. However, the combined OPRM1/COMT 'high-risk' genotype lead to a significant association with the need for rescue (OR: 5.12; 95% CI: 1.12-23.3; p = 0.035). No association was found between OPRM1/COMT 'high-risk' genotype and total morphine dose administered. Conclusion: Combined OPRM1 118A>G and COMT 472G>A genotype might serve as a predictor for the need of rescue morphine in premature and term newborns on mechanical ventilation.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2014
Language Anglais
Journal information "Pharmacogenomics" - Vol. 15, no. 10, p. 1287-1295 (2014)
Peer reviewed yes
Publisher Future Medicine Ltd. ((United Kingdom) London)
issn 1462-2416
e-issn 1744-8042
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Links
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Bibliographic reference Matic, Maja ; Simons, Sinno H.P. ; Van Lingen, Richard A. ; Van Rosmalen, Joost ; Elens, Laure ; et. al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. In: Pharmacogenomics, Vol. 15, no. 10, p. 1287-1295 (2014)
Permanent URL http://hdl.handle.net/2078.1/159836