Gilon, Patrick
[UCL]
Chae, Heeyoung
[UCL]
Rutter, Guy A
Ravier, Magalie A
Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]c) play a crucial role in the control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is controlled by the finely tuned balance between Ca(2+) influx (mainly through voltage-dependent Ca(2+) channels, but also through voltage-independent Ca(2+) channels like store-operated channels) and efflux pathways. Changes in [Ca(2+)]c directly affect [Ca(2+)] in various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi apparatus, secretory granules and lysosomes, as imaged using recombinant targeted probes. Because most of these organelles have specific Ca(2+) influx and efflux pathways, they mutually influence free [Ca(2+)] in the others. In this article, we review the mechanisms of control of [Ca(2+)] in various compartments and particularly the cytosol, the endoplasmic reticulum ([Ca(2+)]ER), acidic stores and mitochondrial matrix ([Ca(2+)]mito), focusing chiefly on the most important physiological stimulus of β-cells, glucose. We also briefly review some alterations of β-cell Ca(2+) homeostasis in Type 2 diabetes.
Bibliographic reference |
Gilon, Patrick ; Chae, Heeyoung ; Rutter, Guy A ; Ravier, Magalie A. Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes. In: Cell Calcium, Vol. 56, no.5, p. 340-361 (2014) |
Permanent URL |
http://hdl.handle.net/2078.1/157119 |